What Does SS-31 Dissolve In? Solvents Explained
Solubility behaviour is where compounds in this library differ most sharply from one another. For SS-31, the determining factors are structural: mitochondria-targeting aromatic-cationic tetrapeptide (cardiolipin-binding).
Overview
Very water-friendly thanks to its charge.
What SS-31 actually is
A tiny four-part peptide that homes in on the powerhouse of the cell, sticking to a lipid (cardiolipin) found only in the inner mitochondrial membrane. Studied around cellular energy, oxidative stress, and aging. Also called Elamipretide.
Supplied for laboratory research use only — not for human or animal use.
Third-party tested by HPLC and LC-MS, ≥99% purity, with a Certificate of Analysis on every order. Ships across Canada.
Technical detail below
How SS-31 behaves in solution
Freely water-soluble owing to its cationic character; dissolves quickly and cleanly. Use low-bind labware, since the strong positive charge promotes adsorption to surfaces.
Commonly worked at 1-5 mg/mL.
Suitable solvents, in order
Structural basis
SS-31 is mitochondria-targeting aromatic-cationic tetrapeptide (cardiolipin-binding). SS-31 (Elamipretide) is a Szeto-Schiller aromatic-cationic tetrapeptide (D-Arg-2',6'-dimethyltyrosine-Lys-Phe-NH2) that concentrates in the inner mitochondrial membrane and binds cardiolipin, the lipid unique to that membrane. Its structure is the reason it is studied specifically at the mitochondrion rather than as a general antioxidant.
What SS-31 is studied for
Studied for selective association with cardiolipin in the inner mitochondrial membrane, the basis of its mitochondrial targeting.
Examined for effects on mitochondrial energy production in research models of mitochondrial dysfunction.
Investigated around reactive-oxygen-species handling at the mitochondrion.
Summarizes published preclinical literature. Provided for research reference only; not a claim of efficacy or a description of human use.
More SS-31 reference
Lyophilized and reconstituted storage conditions, plus the practical working window.
Diluent selection, dissolution behaviour, and the calculator preset for this compound.
The specific chemical routes by which this molecule breaks down, and how to limit each.
Which assays are informative for this molecule, and what to actually check on its COA.
Compound-specific bench practices, and the errors most often made with this molecule.
What to inspect on arrival, and which conditions actually warrant rejecting a vial.
Questions specific to this compound — structure, chemistry, and common misconceptions.
Solubility reference for other compounds
SS-31 is supplied strictly as a research chemical for in-vitro laboratory and research use only. It is not intended for human or animal consumption, diagnostic, or therapeutic use. This page is educational laboratory-handling reference information — not medical advice, not usage guidance, and not a protocol.