What Does DSIP Dissolve In? Solvents Explained
Solubility behaviour is where compounds in this library differ most sharply from one another. For DSIP, the determining factors are structural: nonapeptide (9 residues), strongly acidic.
In plain English
Water-soluble, with an important twist. It has two acidic parts and no basic ones, which means it dissolves well in neutral and slightly alkaline conditions and gets worse as things turn acidic — exactly the reverse of several other compounds here.
What DSIP actually is
DSIP stands for Delta Sleep-Inducing Peptide. It was isolated in the 1970s from the blood of animals in deep sleep — its name records how it was discovered, not a settled explanation of what it does. Decades on, researchers still have not agreed on its mechanism.
Supplied for laboratory research use only — not for human or animal use.
Third-party tested by HPLC and LC-MS, ≥99% purity, with a Certificate of Analysis on every order. Ships across Canada.
Technical detail below
How DSIP behaves in solution
Water-soluble, but distinctly more acidic than the other short peptides here: two acidic residues (Asp, Glu) and no basic residues give it a low isoelectric point. Solubility is therefore good at neutral and alkaline pH and drops as the solution approaches the pI in the acidic range — the opposite pH behaviour to cationic peptides like Selank.
Suitable solvents, in order
Structural basis
DSIP is nonapeptide (9 residues), strongly acidic. DSIP was isolated in the 1970s from the cerebral venous blood of rabbits in slow-wave sleep, in one of the more unusual isolation efforts in neuropeptide research. The name records the assay it was found by rather than a settled mechanism — its physiological role remains debated in the literature.
What DSIP is studied for
Investigated for effects on slow-wave sleep in the models that gave the peptide its name.
Studies have examined interactions with stress-axis signalling.
Explored in preclinical models of oxidative and stress-related neuronal injury.
Notably, decades of work have not converged on an accepted receptor or mechanism — a recurring theme in the literature.
Summarizes published preclinical literature. Provided for research reference only; not a claim of efficacy or a description of human use.
More DSIP reference
Lyophilized and reconstituted storage conditions, plus the practical working window.
Diluent selection, dissolution behaviour, and the calculator preset for this compound.
The specific chemical routes by which this molecule breaks down, and how to limit each.
Which assays are informative for this molecule, and what to actually check on its COA.
Compound-specific bench practices, and the errors most often made with this molecule.
What to inspect on arrival, and which conditions actually warrant rejecting a vial.
Questions specific to this compound — structure, chemistry, and common misconceptions.
Solubility reference for other compounds
DSIP is supplied strictly as a research chemical for in-vitro laboratory and research use only. It is not intended for human or animal consumption, diagnostic, or therapeutic use. This page is educational laboratory-handling reference information — not medical advice, not usage guidance, and not a protocol.