Epithalon
Synthetic tetrapeptide, lyophilised. For in vitro research use only.
Key facts
- Compound:
- Epithalon
- Purity:
- ≥98%, verified by HPLC
- Identity confirmed by:
- LC-MS, independent third-party lab
- CAS number:
- 307297-39-8
- Molecular weight:
- 390.35 g/mol
- Certificate of analysis:
- available on request, verifiable by lot number
- Ships from:
- Vancouver, BC — typically 2–5 business days, tracked and insured, no customs
- Intended use:
- in vitro laboratory research only — not for human or veterinary consumption
Page last updated
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly).
Epithalon, supplied to Canadian researchers by Popular Peptides. One 10 mg vial, ≥98% purity, CAS 307297-39-8, molecular weight 390.35 g/mol. Independently tested by HPLC and LC-MS; the batch-specific Certificate of Analysis is available on request. The lot number on the vial can be checked at popularpeptides.ca/verify. Ships tracked and insured from Vancouver in 2 to 5 business days, with no customs step and no brokerage fee.
Supplied lyophilised for in vitro laboratory research use only; not intended for human or veterinary use.
⚠️ Research Use Only. This compound is intended for in vitro research and laboratory use only. Not for human or veterinary consumption.
Epithalon — compound background
Synthetic tetrapeptide (Ala-Glu-Asp-Gly)
Epithalon is a four-residue peptide derived by Vladimir Khavinson's group from Epithalamin, a pineal gland extract studied in the Soviet Union from the 1970s. It represents the reductionist end of the peptide field — the attempt to identify the shortest sequence retaining the activity of a complex tissue extract. At 390 Da it is the smallest compound in this catalogue by a wide margin.
Solubility & reconstitution
Extremely water-soluble and effectively instantaneous to dissolve. With only four residues, two of them acidic, there is no hydrophobic character and no conformational complexity whatsoever. If an Epithalon vial does not clear immediately, the problem is the vial, not the chemistry.
Storage
Sealed at -20 °C; short 2–8 °C periods are entirely acceptable for a molecule this small and simple. Refrigerate at 2–8 °C. No methionine, cysteine, or tryptophan — light protection is not the priority it is for other compounds here.
Commonly worked with for 3–4 weeks at 2–8 °C.
Stability
Epithalon's one genuine chemical liability is the Asp-Gly isomerisation site. Because isomerisation does not change mass, it is invisible to LC-MS and shows only on the chromatogram — the same analytical blind spot that affects DSIP.
Reading the Certificate of Analysis
Confirm the mass at 390.3 Da. Note that very small, very polar peptides are chromatographically difficult — they elute near the void volume on standard RP-HPLC. A COA that shows good separation for a tetrapeptide reflects a properly developed method; one showing a peak crammed at the solvent front does not tell you much.
Background and handling information is educational, for in-vitro laboratory research use only — not medical advice, dosing, or usage guidance, and not a description of use in humans or animals.
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Epithalon laboratory reference
Epithalon is synthetic tetrapeptide (ala-glu-asp-gly). Handling requirements follow from that chemistry rather than from generic peptide guidance — the pages below cover each aspect specifically for this compound.
Lyophilized and reconstituted storage conditions, plus the practical working window.
Diluent selection, dissolution behaviour, and the calculator preset for this compound.
Which solvents work, why, and what abnormal dissolution behaviour indicates.
The specific chemical routes by which this molecule breaks down, and how to limit each.
Which assays are informative for this molecule, and what to actually check on its COA.
Compound-specific bench practices, and the errors most often made with this molecule.
What to inspect on arrival, and which conditions actually warrant rejecting a vial.
Questions specific to this compound — structure, chemistry, and common misconceptions.
Epithalon compared with
Reference content is educational laboratory-handling information for in-vitro research use only — not medical advice, not usage guidance, and not a protocol.