How to Read a Epitalon Certificate of Analysis (COA)
A Certificate of Analysis is only useful if you know which number on it matters for the compound in front of you. For Epitalon, the informative checks are not the same as for a generic short peptide.
In plain English
Confirm the weight at 390.3. Worth knowing: very small, very water-loving molecules are difficult to separate cleanly in standard testing — they come off almost immediately. A report showing good separation for a four-part molecule reflects a properly developed method; one showing a peak crammed at the very start tells you little.
What Epitalon actually is
Epitalon is the smallest molecule in this library — just four amino acids. It was distilled from an extract of the pineal gland studied in the Soviet Union from the 1970s, representing an attempt to find the shortest sequence that carried the activity of a complex tissue extract.
Supplied for laboratory research use only — not for human or animal use.
Third-party tested by HPLC and LC-MS, ≥99% purity, with a Certificate of Analysis on every order. Ships across Canada.
Technical detail below
Assays that are informative for Epitalon
What to check on the COA
Confirm the mass at 390.3 Da. Note that very small, very polar peptides are chromatographically difficult — they elute near the void volume on standard RP-HPLC. A COA that shows good separation for a tetrapeptide reflects a properly developed method; one showing a peak crammed at the solvent front does not tell you much.
Isoaspartyl species from the Asp-Gly motif, and deletion sequences.
Verify a Popular Peptides batch
Every batch is third-party tested by HPLC and LC-MS with a published Certificate of Analysis (≥99% purity). Enter a lot number to pull the COA for the exact vial in front of you.
What Epitalon is studied for
The most-cited claim in the Epitalon literature, examined in cell-culture models.
Follows from its Epithalamin origin; studied for effects on circadian signalling in animal models.
A long-running Russian research programme examined lifespan endpoints in rodent models.
Epitalon is the flagship of Khavinson's "peptide bioregulator" framework, a distinct research tradition worth understanding as context.
Summarizes published preclinical literature. Provided for research reference only; not a claim of efficacy or a description of human use.
More Epitalon reference
Lyophilized and reconstituted storage conditions, plus the practical working window.
Diluent selection, dissolution behaviour, and the calculator preset for this compound.
Which solvents work, why, and what abnormal dissolution behaviour indicates.
The specific chemical routes by which this molecule breaks down, and how to limit each.
Compound-specific bench practices, and the errors most often made with this molecule.
What to inspect on arrival, and which conditions actually warrant rejecting a vial.
Questions specific to this compound — structure, chemistry, and common misconceptions.
Purity & COA reference for other compounds
Epitalon is supplied strictly as a research chemical for in-vitro laboratory and research use only. It is not intended for human or animal consumption, diagnostic, or therapeutic use. This page is educational laboratory-handling reference information — not medical advice, not usage guidance, and not a protocol.