NAD+
NAD+ coenzyme, lyophilised. For in vitro research use only.
Key facts
- Compound:
- NAD+
- Purity:
- ≥99%, verified by HPLC
- Identity confirmed by:
- LC-MS, independent third-party lab
- Molecular weight:
- 663.43 g/mol
- Certificate of analysis:
- available on request, verifiable by lot number
- Ships from:
- Vancouver, BC — typically 2–5 business days, tracked and insured, no customs
- Intended use:
- in vitro laboratory research only — not for human or veterinary consumption
Page last updated
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme. It is strongly hygroscopic and is supplied lyophilised.
NAD+ for cellular-longevity research, shipped Canada-wide from Vancouver. One 500 mg vial, ≥99% purity, molecular weight 663.43 g/mol. Identity and purity are confirmed by independent HPLC and LC-MS, with the batch-specific Certificate of Analysis available on request. Every lot number is verifiable at popularpeptides.ca/verify. Tracked, insured delivery across Canada — typically 2 to 5 business days, with no customs step and no brokerage fee.
Supplied lyophilised for in vitro laboratory research use only; not intended for human or veterinary use.
Primary literature
- NAD+ metabolism and its roles in cellular processes during ageing — Nature Reviews Molecular Cell Biology, 2021
Covarrubias, Perrone, Grozio & Verdin. The standard reference review on NAD+ decline with age and the enzymes that consume it.
- Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults — Nature Communications, 2018
Randomised, placebo-controlled crossover trial (n=30). Note this tested oral nicotinamide riboside, an NAD+ precursor, not NAD+ itself.
Cited for research context. A citation is not a claim that this compound is safe, effective, or approved for any use.
⚠️ Research Use Only. This compound is intended for in vitro research and laboratory use only. Not for human or veterinary consumption.
NAD+ — compound background
Dinucleotide coenzyme — not a peptide
NAD+ is not a peptide at all, and that single fact governs everything about how it is handled. It is a dinucleotide coenzyme — nicotinamide and adenine linked through a pyrophosphate bridge — present in every living cell and central to redox metabolism. It was first identified in 1906 by Arthur Harden as a small heat-stable factor required for yeast fermentation.
Solubility & reconstitution
Very freely water-soluble — far more so than any peptide here — and the reason vial sizes are measured in hundreds of milligrams rather than single digits. Solutions are clear and faintly yellow at high concentration. Critically, NAD+ is stable in acidic solution and rapidly degraded in alkaline solution, the reverse of the pH preference of many peptides.
Readily exceeds 100 mg/mL; practical limits are set by handling rather than solubility.
Storage
Sealed at -20 °C and rigorously dry. NAD+ is strongly hygroscopic — more so than any peptide in this catalogue — and will draw moisture from room air within minutes of a vial being opened cold. Refrigerate at 2–8 °C and use promptly. Aqueous NAD+ solutions degrade appreciably faster than peptide solutions of comparable storage conditions.
Short: commonly worked with within 1–2 weeks at 2–8 °C, and prepared fresh where accuracy matters.
Stability
Do not apply peptide-handling intuitions to NAD+. It is a nucleotide, its degradation chemistry is hydrolytic rather than oxidative or proteolytic, and its pH sensitivity runs the opposite direction to several peptides in this catalogue.
Reading the Certificate of Analysis
Note the different detection wavelength: nucleotides are read at 260 nm, not the 214 nm used for peptide bonds. Free nicotinamide content is the most informative impurity figure, since it is the direct hydrolysis product. Water content matters more here than for any peptide, given how hygroscopic the material is.
Background and handling information is educational, for in-vitro laboratory research use only — not medical advice, dosing, or usage guidance, and not a description of use in humans or animals.
How much does NAD+ cost in Canada?+
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What sizes of NAD+ are available?+
Is NAD+ third-party tested?+
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NAD+ laboratory reference
NAD+ is dinucleotide coenzyme — not a peptide. Handling requirements follow from that chemistry rather than from generic peptide guidance — the pages below cover each aspect specifically for this compound.
Lyophilized and reconstituted storage conditions, plus the practical working window.
Diluent selection, dissolution behaviour, and the calculator preset for this compound.
Which solvents work, why, and what abnormal dissolution behaviour indicates.
The specific chemical routes by which this molecule breaks down, and how to limit each.
Which assays are informative for this molecule, and what to actually check on its COA.
Compound-specific bench practices, and the errors most often made with this molecule.
What to inspect on arrival, and which conditions actually warrant rejecting a vial.
Questions specific to this compound — structure, chemistry, and common misconceptions.
NAD+ compared with
Reference content is educational laboratory-handling information for in-vitro research use only — not medical advice, not usage guidance, and not a protocol.