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Research Comparison

5-Amino-1MQ vs Epitalon

5-Amino-1MQ and Epitalon are studied in overlapping research areas, which is why they are frequently compared. This is a neutral side-by-side reference drawn from published preclinical literature and laboratory handling data.

Shared research areas:Cellular Longevity
ClassSmall-molecule NNMT inhibitor (methylquinolinium salt) — not a peptideSynthetic tetrapeptide (Ala-Glu-Asp-Gly)
Molecular weightNot specified390.35 g/mol
CAS numberNot assigned / not specified307297-39-8
Purity spec≥99%≥98%
Research areasMetabolic, Cellular LongevityCellular Longevity, Circadian & Sleep
Primary diluentBacteriostatic water (0.9% benzyl alcohol)Sterile or bacteriostatic water
Working windowCommonly worked with for several weeks at 2-8 °C in preserved diluent.Commonly worked with for 3–4 weeks at 2–8 °C.
Lead degradation routeMicrobial growth in non-preserved diluent — a container problem rather than a molecular one.Aspartate-glycine isomerisation — the Asp-Gly motif is among the most isomerisation-prone sequences in peptide chemistry, and Epitalon contains it.
Freeze–thawTolerant of freeze-thaw — there is no tertiary structure to lose. Aliquoting is still good practice to limit repeated exposure of the stock.Highly tolerant. A four-residue peptide has essentially no structure to disrupt, making this one of the more freeze-tolerant compounds in the catalogue.
Light sensitivityNo specific light requirement beyond normal practice.No specific light requirement beyond normal practice.

How they actually differ

Comparing the two: 5-Amino-1MQ is small-molecule nnmt inhibitor (methylquinolinium salt) — not a peptide, while Epitalon is synthetic tetrapeptide (ala-glu-asp-gly) — different molecular classes with different handling consequences; they call for different primary diluents (bacteriostatic water (0.9% benzyl alcohol) versus sterile or bacteriostatic water); their leading degradation routes differ (microbial growth in non-preserved diluent for 5-Amino-1MQ, aspartate-glycine isomerisation for Epitalon), so the storage precautions that matter are not the same; their practical working windows differ once reconstituted. The sections below set out each in full.

5-Amino-1MQ — origin

5-Amino-1MQ is a small quinolinium molecule characterised as a first-in-class inhibitor of NNMT (nicotinamide N-methyltransferase), an enzyme studied at the intersection of adipocyte metabolism and the cellular NAD+/methylation pool. It is not an amino-acid chain, which is why it sits apart from every peptide in this catalogue.

Epitalon — origin

Epitalon is a four-residue peptide derived by Vladimir Khavinson's group from Epithalamin, a pineal gland extract studied in the Soviet Union from the 1970s. It represents the reductionist end of the peptide field — the attempt to identify the shortest sequence retaining the activity of a complex tissue extract. At 390 Da it is the smallest compound in this catalogue by a wide margin.

5-Amino-1MQ research themes

NNMT inhibition

The defining mechanism — preclinical work has examined how blocking NNMT shifts methylation flux and NAD+ salvage in metabolic tissue models.

Adipocyte energy metabolism

Studied in fat-cell models for effects on cellular energy handling and lipid metabolism.

NAD+ economy

Because NNMT consumes a methyl group tied to the NAD+ precursor pool, it is studied alongside the wider NAD+ research field.

Epitalon research themes

Telomerase activation

The most-cited claim in the Epitalon literature, examined in cell-culture models.

Pineal and melatonin rhythm

Follows from its Epithalamin origin; studied for effects on circadian signalling in animal models.

Ageing models

A long-running Russian research programme examined lifespan endpoints in rodent models.

Peptide bioregulator concept

Epitalon is the flagship of Khavinson's "peptide bioregulator" framework, a distinct research tradition worth understanding as context.

5-Amino-1MQ handling

  • Let the sealed vial reach room temperature before opening so moisture does not condense onto the powder.
  • For cell-based assays, prepare a concentrated DMSO stock and dilute into aqueous buffer rather than dissolving directly at high concentration in medium.
  • Label aliquots with reconstitution date and diluent.

Epitalon handling

  • Do not over-engineer storage for this compound — refrigeration and a sound seal are genuinely sufficient.
  • Avoid prolonged storage of reconstituted solution, since Asp-Gly isomerisation is slow but cumulative.
  • Verify the analytical method behind any purity figure, as short polar peptides are easy to under-resolve.

Both third-party tested

Every Popular Peptides batch of 5-Amino-1MQ and Epitalon is independently tested by HPLC and LC-MS with a published Certificate of Analysis. Enter a lot number to pull the COA for a specific vial.

Verify a batchPublished COAsHow we test

5-Amino-1MQ reference

Full 5-Amino-1MQ reference 5-Amino-1MQ storage 5-Amino-1MQ reconstitution 5-Amino-1MQ calculator5-Amino-1MQ product details

Epitalon reference

Full Epitalon reference Epitalon storage Epitalon reconstitution Epitalon calculatorEpitalon product details

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5-Amino-1MQ and Epitalon are supplied strictly as research chemicals for in-vitro laboratory and research use only. They are not intended for human or animal consumption, diagnostic, or therapeutic use. This comparison summarizes published preclinical literature and laboratory handling data; it is not medical advice, not a claim of efficacy, and not usage guidance.