FOXO4-DRI10mg research peptide · Canada
Also written and searched as FOX04-DRI — same compound, same vial, same lot number.
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- Ships from Vancouver — no customs, no duties
- Dispatched in 1–2 business days · tracked & insured
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Key facts
- Compound:
- FOXO4-DRI
- Also known as:
- FOX04-DRI
- Purity:
- ≥99%, verified by HPLC
- Tested by:
- independent third-party lab (HPLC purity and measured content)
- CAS number:
- 2460055-10-9
- Molecular weight:
- 5358.2 g/mol
- Certificate of analysis:
- for members only · join free
- Ships from:
- Vancouver, BC — typically 2–5 business days, tracked and insured, no customs
- Intended use:
- in vitro laboratory research only — not for human or veterinary consumption
Page last updated
FOXO4-DRI (also written FOX04-DRI, or Proxofim) is the “zombie cell” peptide you may have heard about. It’s designed to interfere with a protein connection that helps old, worn-out cells survive, and it’s one of the most talked-about compounds in ageing research. It’s pricey because it’s built from mirror-image amino acids, which are hard to make. It comes as a freeze-dried powder in a 10 mg vial.
FOXO4-DRI for cellular-senescence research, supplied to Canadian researchers by Popular Peptides. One 10 mg vial, ≥99% purity, CAS 2460055-10-9, molecular weight 5358.2 g/mol. Tested by an independent lab for purity and content (HPLC). Certificates of Analysis (COAs) are for members only. The compound was first described in a 2017 Cell study examining selective apoptosis of senescent cells in cell-culture and mouse models. Ships tracked and insured from Vancouver by Canada Post Xpresspost, usually 1 to 4 business days, with no customs step and no brokerage fee.
Sold as a laboratory research material only, for in vitro use. It isn’t a medicine and isn’t meant for people or animals.
Primary literature
- Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging — Cell, 2017
The founding study: interfering with FOXO4–p53 caused selective apoptosis of senescent cells in culture and was examined in chemotoxicity, fast-ageing and naturally aged mouse models.
- Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes — Frontiers in Bioengineering and Biotechnology, 2021
In vitro human-cell work: at 25 µM it cleared much of a late-passage chondrocyte population while sparing early-passage cells.
Cited for research context. A citation is not a claim that this compound is safe, effective, or approved for any use.
Research Use Only. This compound is a laboratory material for in vitro research. It is not a medicine and is not for human or veterinary use. If you’re looking for help with your health, please speak with a doctor or pharmacist.
New to research compounds? Start here. Buying in Canada: why domestic means no customs. Checking quality: how to read a COA.
What is FOXO4-DRI? FOXO4-DRI at a glance
In short: FOXO4-DRI is $219.99 CAD at Popular Peptides Canada, ships from Vancouver with no customs, and usually arrives in 1–4 business days.
- What it is
- FOXO4-DRI (also written FOX04-DRI, or Proxofim) is the “zombie cell” peptide you may have heard about. It’s designed to interfere with a protein connection that helps old, worn-out cells survive, and it’s one of the most talked-about compounds in ageing research.
- Price
- $219.99 CAD. Prices are in Canadian dollars, so there’s no exchange-rate surprise.
- Size
- 10mg
- Purity
- ≥99%, tested by an independent lab (HPLC purity and content)
- Ships from
- Vancouver, BC, to anywhere in Canada. It never crosses a border, so there’s no customs and no brokerage fee.
- Delivery
- Dispatched in 1–2 business days by Canada Post Xpresspost, tracked and insured. Usually 1–2 days in BC, 2–3 on the Prairies and to major Ontario and Québec cities, 2–4 in Atlantic Canada.
- Shipping cost
- Free over $300 CAD, otherwise a flat $24.99.
- Lab report
- Certificates of Analysis are for members only.
- Pay with
- Visa, Mastercard, Amex, Discover or Interac e-Transfer (an extra 10% off by e-Transfer).
- Sold for
- Laboratory research only. It isn’t a medicine and isn’t meant for people or animals.
New to this? Our plain-language guide explains everything from lab reports to delivery, and our Canada vs imported guide shows why ordering inside Canada is simpler.
FOXO4-DRI — compound background
46-residue all-D retro-inverso peptide
FOXO4-DRI was designed in the laboratory of Peter de Keizer (Erasmus University Medical Center) and published in Cell in 2017 (Baar et al.). It mimics the region of the transcription factor FOXO4 that binds p53, but is built from D-amino acids in reversed order — a retro-inverso design that keeps the side-chain layout while making the backbone unrecognisable to proteases. A cationic, arginine-rich tail derived from the HIV-TAT cell-penetrating sequence carries it into cells.
Solubility & reconstitution
Strongly basic — the sequence carries many arginine and lysine residues — so it dissolves readily in plain aqueous diluent without acidification. The same positive charge makes it stick to negatively charged surfaces such as untreated glass.
Commonly worked at 1-5 mg/mL.
Storage
Sealed powder is stable at -20 °C long-term; keep desiccated. Refrigerate at 2-8 °C, protected from light, and aliquot for anything beyond short-term use.
Commonly worked with for 2-3 weeks at 2-8 °C in bacteriostatic water.
Stability
Because every residue is a D-amino acid, ordinary proteases barely cleave it — chemical routes (deamidation, oxidation) and surface loss matter far more than enzymatic breakdown.
Reading the Certificate of Analysis
Check the HPLC purity and the measured content per vial. For a 46-residue, highly cationic peptide the gross powder weight includes counter-ion (typically trifluoroacetate) and water, so measured peptide content is the more informative number. Where mass data is given, the target is about 5358 Da.
Background and handling information is educational, for in-vitro laboratory research use only — not medical advice, dosing, or usage guidance, and not a description of use in humans or animals.
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FOXO4-DRI laboratory reference
FOXO4-DRI is 46-residue all-d retro-inverso peptide. Handling requirements follow from that chemistry rather than from generic peptide guidance — the pages below cover each aspect specifically for this compound.
FOXO4-DRI compared with
Reference content is educational laboratory-handling information for in-vitro research use only — not medical advice, not usage guidance, and not a protocol.