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What Does Semax Dissolve In? Solvents Explained

Solubility behaviour is where compounds in this library differ most sharply from one another. For Semax, the determining factors are structural: synthetic heptapeptide, acth(4-7) analogue.

Synthetic heptapeptide, ACTH(4-7) analogueCognitive & Neurological

In plain English

Completely at home in water. It is small and strongly water-attracting, so it dissolves instantly at any strength you would realistically work at. There is no solvent puzzle to solve with this one.

What Semax actually is

Semax was built in a Moscow laboratory by taking a four-amino-acid piece of ACTH — a stress hormone — and adding a short tail so enzymes could not destroy it within seconds. That piece was chosen specifically because it carries nerve-related properties without the hormonal effects of the full molecule.

Supplied for laboratory research use only — not for human or animal use.

Research-grade Semax

Third-party tested by HPLC and LC-MS, ≥99% purity, with a Certificate of Analysis on every order. Ships across Canada.

Technical detail below

How Semax behaves in solution

Small, highly polar, and freely water-soluble at any concentration used in laboratory work. At 813.9 Da it is among the smallest compounds in this catalogue, and dissolution is essentially instantaneous.

Suitable solvents, in order

Primary choiceSterile or bacteriostatic water
Alternative 1Saline
Alternative 2Phosphate-buffered saline

Structural basis

Semax is synthetic heptapeptide, acth(4-7) analogue. Semax was developed at the Institute of Molecular Genetics in Moscow by attaching the Pro-Gly-Pro tripeptide to the ACTH(4-7) fragment. That C-terminal addition is the entire design rationale: it confers resistance to the aminopeptidases that clear the parent fragment within seconds, without retaining the corticotropic activity of full-length ACTH.

What Semax is studied for

BDNF expression

One of the most-cited research findings is upregulation of brain-derived neurotrophic factor in animal models.

Neuroprotection under ischemia

A substantial Russian literature examines the compound in cerebral ischemia models.

Attention and memory pathways

Investigated in behavioural models measuring attention and memory consolidation.

Non-corticotropic design

The ACTH(4-7) fragment was selected specifically because it lacks the hormonal activity of the full sequence.

Summarizes published preclinical literature. Provided for research reference only; not a claim of efficacy or a description of human use.

More Semax reference

Solubility reference for other compounds

Semax overview Semax calculatorSemax product details

Semax is supplied strictly as a research chemical for in-vitro laboratory and research use only. It is not intended for human or animal consumption, diagnostic, or therapeutic use. This page is educational laboratory-handling reference information — not medical advice, not usage guidance, and not a protocol.