Semax
ACTH-derived peptide, lyophilised. For in vitro research use only.
Key facts
- Compound:
- Semax
- Purity:
- ≥99%, verified by HPLC
- Identity confirmed by:
- LC-MS, independent third-party lab
- CAS number:
- 80714-61-0
- Molecular weight:
- 813.94 g/mol
- Certificate of analysis:
- available on request, verifiable by lot number
- Ships from:
- Vancouver, BC — typically 2–5 business days, tracked and insured, no customs
- Intended use:
- in vitro laboratory research only — not for human or veterinary consumption
Page last updated
Semax is a synthetic peptide derived from the ACTH(4-10) fragment.
Order Semax in Canada with the paperwork to back it. One 10 mg vial, ≥99% purity, CAS 80714-61-0, molecular weight 813.94 g/mol. Third-party HPLC and LC-MS on every batch, with the batch-specific Certificate of Analysis available on request. Lot-level verification is open to anyone at popularpeptides.ca/verify. Tracked, insured delivery from Vancouver, BC — typically 2 to 5 business days, with no customs step and no brokerage fee.
Supplied lyophilised for in vitro laboratory research use only; not intended for human or veterinary use.
Primary literature
- Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus — Brain Research, 2006
Dolotov et al. Showed the ACTH(4-10) analogue raises BDNF and trkB expression in rat hippocampus, the basis of the nootropic hypothesis.
Cited for research context. A citation is not a claim that this compound is safe, effective, or approved for any use.
⚠️ Research Use Only. This compound is intended for in vitro research and laboratory use only. Not for human or veterinary consumption.
Semax — compound background
Synthetic heptapeptide, ACTH(4-7) analogue
Semax was developed at the Institute of Molecular Genetics in Moscow by attaching the Pro-Gly-Pro tripeptide to the ACTH(4-7) fragment. That C-terminal addition is the entire design rationale: it confers resistance to the aminopeptidases that clear the parent fragment within seconds, without retaining the corticotropic activity of full-length ACTH.
Solubility & reconstitution
Small, highly polar, and freely water-soluble at any concentration used in laboratory work. At 813.9 Da it is among the smallest compounds in this catalogue, and dissolution is essentially instantaneous.
Storage
Sealed at -20 °C. Short periods at 2–8 °C are acceptable given the small, robust structure. Refrigerate at 2–8 °C, protected from light. The N-terminal methionine is the compound's principal chemical liability.
Commonly worked with for 2–3 weeks at 2–8 °C.
Stability
The Pro-Gly-Pro extension protects against enzymatic degradation in biological media. It provides no protection against oxidation in a storage vial — those are different problems with different countermeasures.
Reading the Certificate of Analysis
Verify the molecular ion at 813.9 Da and check for a +16 Da oxidised species. For a peptide this short, RP-HPLC resolves related substances well, so a clean single peak is a strong quality signal.
Background and handling information is educational, for in-vitro laboratory research use only — not medical advice, dosing, or usage guidance, and not a description of use in humans or animals.
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Semax laboratory reference
Semax is synthetic heptapeptide, acth(4-7) analogue. Handling requirements follow from that chemistry rather than from generic peptide guidance — the pages below cover each aspect specifically for this compound.
Lyophilized and reconstituted storage conditions, plus the practical working window.
Diluent selection, dissolution behaviour, and the calculator preset for this compound.
Which solvents work, why, and what abnormal dissolution behaviour indicates.
The specific chemical routes by which this molecule breaks down, and how to limit each.
Which assays are informative for this molecule, and what to actually check on its COA.
Compound-specific bench practices, and the errors most often made with this molecule.
What to inspect on arrival, and which conditions actually warrant rejecting a vial.
Questions specific to this compound — structure, chemistry, and common misconceptions.
Semax compared with
Reference content is educational laboratory-handling information for in-vitro research use only — not medical advice, not usage guidance, and not a protocol.