What Does PNC-27 Dissolve In? Solvents Explained
Solubility behaviour is where compounds in this library differ most sharply from one another. For PNC-27, the determining factors are structural: membranolytic fusion peptide (32 residues): p53-derived domain + membrane-penetrating leader.
Overview
Being membrane-active it can clump at high strengths — dilute from a stock instead of pushing concentration.
What PNC-27 actually is
A designed peptide studied only in the lab, in cell culture, for a striking trick: it latches onto HDM-2 on certain cancer cells and pokes holes in their outer membrane, breaking those cells apart while reportedly leaving healthy cells alone.
Supplied for laboratory research use only — not for human or animal use.
Third-party tested by HPLC and LC-MS, ≥99% purity, with a Certificate of Analysis on every order. Ships across Canada.
Technical detail below
How PNC-27 behaves in solution
An amphipathic, membrane-active peptide that can aggregate at higher concentrations. Prepare a stock and dilute into the assay system rather than working at the solubility limit; some cell-assay protocols use a DMSO stock.
Work below the aggregation point; higher concentrations offer no advantage and risk precipitation.
Suitable solvents, in order
Structural basis
PNC-27 is membranolytic fusion peptide (32 residues): p53-derived domain + membrane-penetrating leader. PNC-27 is a designed 32-residue peptide fusing a p53-derived region that binds HDM-2 with a membrane-penetrating leader sequence. It is studied strictly in vitro for a reported ability to form pores in the membranes of cancer cells that display HDM-2 at their surface, while reportedly sparing normal cells.
What PNC-27 is studied for
Studied for binding HDM-2 displayed on the surface of certain cancer cells in vitro.
Examined for forming transmembrane pores that lead to lysis of targeted cells in culture.
Investigated for a reported preference for tumour cells over normal cells in preclinical cell-culture models.
Summarizes published preclinical literature. Provided for research reference only; not a claim of efficacy or a description of human use.
More PNC-27 reference
Lyophilized and reconstituted storage conditions, plus the practical working window.
Diluent selection, dissolution behaviour, and the calculator preset for this compound.
The specific chemical routes by which this molecule breaks down, and how to limit each.
Which assays are informative for this molecule, and what to actually check on its COA.
Compound-specific bench practices, and the errors most often made with this molecule.
What to inspect on arrival, and which conditions actually warrant rejecting a vial.
Questions specific to this compound — structure, chemistry, and common misconceptions.
Solubility reference for other compounds
PNC-27 is supplied strictly as a research chemical for in-vitro laboratory and research use only. It is not intended for human or animal consumption, diagnostic, or therapeutic use. This page is educational laboratory-handling reference information — not medical advice, not usage guidance, and not a protocol.