PNC-275mg research peptide · Canada
Buy 2 and save $14.00 — 10% off every unit
- Ships from Vancouver — no customs, no duties
- Dispatched in 1–2 business days · tracked & insured
Add $230.01 more for free shipping
Key facts
- Compound:
- PNC-27
- Purity:
- ≥99%, verified by HPLC
- Tested by:
- independent third-party lab (HPLC purity and measured content)
- Certificate of analysis:
- available on request · members-only lab results
- Ships from:
- Vancouver, BC — typically 2–5 business days, tracked and insured, no customs
- Intended use:
- in vitro laboratory research only — not for human or veterinary consumption
Page last updated
PNC-27 is a lab-made peptide built from a piece of a protein called p53 joined to a “carrier” that helps it get into cells. It’s studied in cell cultures in the lab. Please note: PNC-27 is not a cancer treatment. It comes as a freeze-dried powder in a 5 mg vial.
PNC-27 for cellular-longevity research, shipped Canada-wide from Vancouver. One 5 mg vial, ≥99% purity. Tested by an independent lab for purity and content (HPLC), and the lab report (COA) for your batch is available on request. Tracked, insured delivery across Canada — by Canada Post Xpresspost, usually 1 to 4 business days, with no customs step and no brokerage fee.
Sold as a laboratory research material only, for in vitro use. It isn’t a medicine and isn’t meant for people or animals.
Primary literature
- Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells — PNAS, 2001
Kanovsky et al. Preclinical in vitro precursor work to PNC-27: peptides from p53’s mdm-2-binding domain tested on transformed vs untransformed cells in culture.
- Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes — PNAS, 2010
Sarafraz-Yazdi et al. Preclinical in vitro study of PNC-27 binding membrane HDM-2 in cancer cell lines. No human studies.
Cited for research context. A citation is not a claim that this compound is safe, effective, or approved for any use.
Research Use Only. This compound is a laboratory material for in vitro research. It is not a medicine and is not for human or veterinary use. If you’re looking for help with your health, please speak with a doctor or pharmacist.
New to research compounds? Start here. Buying in Canada: why domestic means no customs. Checking quality: how to read a COA.
What is PNC-27? PNC-27 at a glance
In short: PNC-27 is $69.99 CAD at Popular Peptides Canada, ships from Vancouver with no customs, and usually arrives in 1–4 business days.
- What it is
- PNC-27 is a lab-made peptide built from a piece of a protein called p53 joined to a “carrier” that helps it get into cells. It’s studied in cell cultures in the lab.
- Price
- $69.99 CAD. Prices are in Canadian dollars, so there’s no exchange-rate surprise.
- Size
- 5mg
- Purity
- ≥99%, tested by an independent lab (HPLC purity and content)
- Ships from
- Vancouver, BC, to anywhere in Canada. It never crosses a border, so there’s no customs and no brokerage fee.
- Delivery
- Dispatched in 1–2 business days by Canada Post Xpresspost, tracked and insured. Usually 1–2 days in BC, 2–3 on the Prairies and to major Ontario and Québec cities, 2–4 in Atlantic Canada.
- Shipping cost
- Free over $300 CAD, otherwise a flat $20.
- Lab report
- Available on request. Lab results are kept in our members-only area.
- Pay with
- Visa, Mastercard, Apple Pay, Google Pay or Interac e-Transfer (an extra 10% off by e-Transfer).
- Sold for
- Laboratory research only. It isn’t a medicine and isn’t meant for people or animals.
New to this? Our plain-language guide explains everything from lab reports to delivery, and our Canada vs imported guide shows why ordering inside Canada is simpler.
PNC-27 — compound background
Membranolytic fusion peptide (32 residues): p53-derived domain + membrane-penetrating leader
PNC-27 is a designed 32-residue peptide fusing a p53-derived region that binds HDM-2 with a membrane-penetrating leader sequence. It is studied strictly in vitro for a reported ability to form pores in the membranes of cancer cells that display HDM-2 at their surface, while reportedly sparing normal cells.
Solubility & reconstitution
An amphipathic, membrane-active peptide that can aggregate at higher concentrations. Prepare a stock and dilute into the assay system rather than working at the solubility limit; some cell-assay protocols use a DMSO stock.
Work below the aggregation point; higher concentrations offer no advantage and risk precipitation.
Storage
Sealed powder stable at -20 °C. Refrigerate at 2-8 °C and use promptly; prepare fresh working dilutions for assays.
Short — prepare working solutions close to use.
Stability
Its membrane activity is the point of the molecule and also the reason it does not behave like a simple soluble peptide in handling.
Reading the Certificate of Analysis
Confirm identity by mass and check purity by RP-HPLC; for a 32-mer, deletion sequences are the characteristic synthesis impurity and should be resolved from the main peak.
Background and handling information is educational, for in-vitro laboratory research use only — not medical advice, dosing, or usage guidance, and not a description of use in humans or animals.
How much does PNC-27 cost in Canada?+
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What sizes of PNC-27 are available?+
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PNC-27 laboratory reference
PNC-27 is membranolytic fusion peptide (32 residues): p53-derived domain + membrane-penetrating leader. Handling requirements follow from that chemistry rather than from generic peptide guidance — the pages below cover each aspect specifically for this compound.
Lyophilized and reconstituted storage conditions, plus the practical working window.
Diluent selection, dissolution behaviour, and the calculator preset for this compound.
Which solvents work, why, and what abnormal dissolution behaviour indicates.
The specific chemical routes by which this molecule breaks down, and how to limit each.
Which assays are informative for this molecule, and what to actually check on its COA.
Compound-specific bench practices, and the errors most often made with this molecule.
What to inspect on arrival, and which conditions actually warrant rejecting a vial.
Questions specific to this compound — structure, chemistry, and common misconceptions.
PNC-27 compared with
Reference content is educational laboratory-handling information for in-vitro research use only — not medical advice, not usage guidance, and not a protocol.