PNC-27
Synthetic peptide (HDM-2-binding domain), lyophilised. For in vitro research use only.
Key facts
- Compound:
- PNC-27
- Purity:
- ≥99%, verified by HPLC
- Identity confirmed by:
- LC-MS, independent third-party lab
- Certificate of analysis:
- available on request, verifiable by lot number
- Ships from:
- Vancouver, BC — typically 2–5 business days, tracked and insured, no customs
- Intended use:
- in vitro laboratory research only — not for human or veterinary consumption
Page last updated
PNC-27 is a synthetic peptide incorporating an HDM-2-binding domain.
PNC-27 for cellular-longevity research, shipped Canada-wide from Vancouver. One 5 mg vial, ≥99% purity. Identity and purity are confirmed by independent HPLC and LC-MS, with the batch-specific Certificate of Analysis available on request. Every lot number is verifiable at popularpeptides.ca/verify. Tracked, insured delivery across Canada — typically 2 to 5 business days, with no customs step and no brokerage fee.
Supplied lyophilised for in vitro laboratory research use only; not intended for human or veterinary use.
⚠️ Research Use Only. This compound is intended for in vitro research and laboratory use only. Not for human or veterinary consumption.
PNC-27 — compound background
Membranolytic fusion peptide (32 residues): p53-derived domain + membrane-penetrating leader
PNC-27 is a designed 32-residue peptide fusing a p53-derived region that binds HDM-2 with a membrane-penetrating leader sequence. It is studied strictly in vitro for a reported ability to form pores in the membranes of cancer cells that display HDM-2 at their surface, while reportedly sparing normal cells.
Solubility & reconstitution
An amphipathic, membrane-active peptide that can aggregate at higher concentrations. Prepare a stock and dilute into the assay system rather than working at the solubility limit; some cell-assay protocols use a DMSO stock.
Work below the aggregation point; higher concentrations offer no advantage and risk precipitation.
Storage
Sealed powder stable at -20 °C. Refrigerate at 2-8 °C and use promptly; prepare fresh working dilutions for assays.
Short — prepare working solutions close to use.
Stability
Its membrane activity is the point of the molecule and also the reason it does not behave like a simple soluble peptide in handling.
Reading the Certificate of Analysis
Confirm identity by mass and check purity by RP-HPLC; for a 32-mer, deletion sequences are the characteristic synthesis impurity and should be resolved from the main peak.
Background and handling information is educational, for in-vitro laboratory research use only — not medical advice, dosing, or usage guidance, and not a description of use in humans or animals.
How much does PNC-27 cost in Canada?+
Where can I buy PNC-27 in Canada?+
What sizes of PNC-27 are available?+
Is PNC-27 third-party tested?+
What purity is PNC-27?+
Is PNC-27 intended for human or veterinary use?+
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PNC-27 laboratory reference
PNC-27 is membranolytic fusion peptide (32 residues): p53-derived domain + membrane-penetrating leader. Handling requirements follow from that chemistry rather than from generic peptide guidance — the pages below cover each aspect specifically for this compound.
Lyophilized and reconstituted storage conditions, plus the practical working window.
Diluent selection, dissolution behaviour, and the calculator preset for this compound.
Which solvents work, why, and what abnormal dissolution behaviour indicates.
The specific chemical routes by which this molecule breaks down, and how to limit each.
Which assays are informative for this molecule, and what to actually check on its COA.
Compound-specific bench practices, and the errors most often made with this molecule.
What to inspect on arrival, and which conditions actually warrant rejecting a vial.
Questions specific to this compound — structure, chemistry, and common misconceptions.
PNC-27 compared with
Reference content is educational laboratory-handling information for in-vitro research use only — not medical advice, not usage guidance, and not a protocol.