PNC-27
Membrane-disrupting peptide studied in in-vitro oncology research (HDM-2 binding, tumour-cell lysis).
Molecular reference
Research background
PNC-27 is a peptide studied almost exclusively in cancer research. In the lab it is examined for a striking reported behaviour: binding HDM-2 on the surface of certain tumour cells and forming pores in their membranes, causing those cells to break apart while reportedly leaving healthy cells intact in preclinical models — searched around tumour cell, apoptosis, and oncology. It is supplied strictly for in-vitro laboratory study.
That reported selectivity for tumour-cell membranes is the whole reason it draws research interest.
Summarizes published preclinical literature. Provided for research reference only; not a claim of efficacy or a description of human use.
Reconstitution
- Supplied as a lyophilized (freeze-dried) powder for laboratory reconstitution.
- Bacteriostatic water (0.9% benzyl alcohol) is the most common reconstitution solvent for multi-use research handling; sterile or acetic-acid solutions are used for specific compounds.
- Introduce solvent slowly against the vial wall rather than directly onto the powder, and allow it to dissolve without vigorous shaking.
- Use the reconstitution calculator to determine solvent volume for a target concentration in your protocol.
Storage & handling
- Lyophilized powder: store sealed at -20 °C for long-term stability; short periods at 2–8 °C are generally acceptable.
- Once reconstituted: refrigerate at 2–8 °C and protect from light; use within the compound-specific window noted on the COA.
- Avoid repeated freeze–thaw cycles of reconstituted solution.
- Keep away from direct light and heat at all times.
Purity & verification
Every Popular Peptides batch is third-party tested by HPLC and LC-MS with a published Certificate of Analysis (≥99% purity).
PNC-27 in depth
Lyophilized and reconstituted storage conditions, plus the practical working window.
Diluent selection, dissolution behaviour, and the calculator preset for this compound.
Which solvents work, why, and what abnormal dissolution behaviour indicates.
The specific chemical routes by which this molecule breaks down, and how to limit each.
Which assays are informative for this molecule, and what to actually check on its COA.
Compound-specific bench practices, and the errors most often made with this molecule.
What to inspect on arrival, and which conditions actually warrant rejecting a vial.
Questions specific to this compound — structure, chemistry, and common misconceptions.
Compared with other compounds
Related compounds
PNC-27 is sold strictly as a research chemical for in-vitro laboratory and research use only. It is not intended for human or animal consumption, diagnostic, or therapeutic use. This page is educational reference information, not medical or usage guidance.