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What to Check When Your MOTS-C Arrives

Not every irregularity on arrival is a defect, and not every compound is defective under the same conditions. Here is what actually matters when a MOTS-C shipment arrives.

Mitochondrial-derived peptide, 16 residuesMetabolicCellular Longevity

In plain English

Check that the packaging kept light out and that the powder is white rather than yellowed. Any yellow or tan tint means light damage has already started and is a genuine reason to reject the vial.

What MOTS-C actually is

MOTS-c has one of the more surprising origins in this catalogue: its instructions are written not in the DNA of the cell nucleus but inside the separate, much smaller genome carried by mitochondria — the structures that produce most of a cell's energy. It is studied as a signal they send out to the rest of the cell.

Supplied for laboratory research use only — not for human or animal use.

Research-grade MOTS-C

Third-party tested by HPLC and LC-MS, ≥99% purity, with a Certificate of Analysis on every order. Ships across Canada.

Technical detail below

Arrival inspection for MOTS-C

Confirm the vial was shipped with light protection and the cake is white rather than yellowed. Discolouration in a tryptophan-containing peptide is a meaningful oxidation signal, not a cosmetic variation.

Storage on arrival

On receiptSealed at -20 °C, dry and dark.
Once reconstitutedRefrigerate at 2–8 °C with light protection. Both oxidation-prone residue types are present, so the two main degradation pathways operate simultaneously.
Working windowCommonly worked with for 2–3 weeks at 2–8 °C.

Documentation to check

Confirm the mass near 2174.5 Da and scrutinise the region above it for +16 and +32 Da satellites. Because both methionine and tryptophan can oxidise, multiple oxidised species may be present — a cluster of small satellite peaks is more diagnostic here than a single one.

What MOTS-C is studied for

Mitochondrial-derived signalling

Part of a novel class demonstrating that mitochondria encode peptides acting systemically.

AMPK pathway

The most-studied signalling interaction, examined in metabolic and exercise models.

Insulin sensitivity

Investigated in glucose-metabolism research models.

Exercise and longevity biology

Studies have examined MOTS-c expression in relation to physical activity and ageing in animal models.

Summarizes published preclinical literature. Provided for research reference only; not a claim of efficacy or a description of human use.

More MOTS-C reference

Shipping & Receiving reference for other compounds

MOTS-C overview MOTS-C calculatorMOTS-C product details

MOTS-C is supplied strictly as a research chemical for in-vitro laboratory and research use only. It is not intended for human or animal consumption, diagnostic, or therapeutic use. This page is educational laboratory-handling reference information — not medical advice, not usage guidance, and not a protocol.