MOTS-C
Mitochondria-derived peptide, lyophilised. For in vitro research use only.
Key facts
- Compound:
- MOTS-C
- Purity:
- ≥98%, verified by HPLC
- Identity confirmed by:
- LC-MS, independent third-party lab
- Molecular weight:
- 2174.5 g/mol
- Certificate of analysis:
- available on request, verifiable by lot number
- Ships from:
- Vancouver, BC — typically 2–5 business days, tracked and insured, no customs
- Intended use:
- in vitro laboratory research only — not for human or veterinary consumption
Page last updated
MOTS-c is a mitochondria-derived peptide.
Order MOTS-C in Canada with the paperwork to back it. Available in 20 mg and 10 mg, ≥98% purity, molecular weight 2174.5 g/mol. Third-party HPLC and LC-MS on every batch, with the batch-specific Certificate of Analysis available on request. Lot-level verification is open to anyone at popularpeptides.ca/verify. Tracked, insured delivery from Vancouver, BC — typically 2 to 5 business days, with no customs step and no brokerage fee.
Supplied lyophilised for in vitro laboratory research use only; not intended for human or veterinary use.
Primary literature
- The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance — Cell Metabolism, 2015
The paper that established MOTS-c as a mitochondrially encoded regulator of metabolic homeostasis.
Cited for research context. A citation is not a claim that this compound is safe, effective, or approved for any use.
⚠️ Research Use Only. This compound is intended for in vitro research and laboratory use only. Not for human or veterinary consumption.
MOTS-C — compound background
Mitochondrial-derived peptide, 16 residues
MOTS-c is encoded not in nuclear DNA but within the mitochondrial genome — specifically an open reading frame inside the 12S ribosomal RNA gene. Its discovery helped establish that mitochondria encode short signalling peptides that act on the rest of the cell, a genuinely recent addition to cell biology and the reason the compound attracted rapid research interest.
Solubility & reconstitution
Water-soluble, with a net positive charge from three basic residues. The sequence contains both methionine and tryptophan, which makes it one of the more chemically reactive peptides in this catalogue despite its modest length.
Storage
Sealed at -20 °C, dry and dark. Refrigerate at 2–8 °C with light protection. Both oxidation-prone residue types are present, so the two main degradation pathways operate simultaneously.
Commonly worked with for 2–3 weeks at 2–8 °C.
Stability
MOTS-c is the clearest case in this catalogue for strict oxygen and light control: it carries the two most reactive proteinogenic side chains in a single short sequence.
Reading the Certificate of Analysis
Confirm the mass near 2174.5 Da and scrutinise the region above it for +16 and +32 Da satellites. Because both methionine and tryptophan can oxidise, multiple oxidised species may be present — a cluster of small satellite peaks is more diagnostic here than a single one.
Background and handling information is educational, for in-vitro laboratory research use only — not medical advice, dosing, or usage guidance, and not a description of use in humans or animals.
How much does MOTS-C cost in Canada?+
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What sizes of MOTS-C are available?+
Is MOTS-C third-party tested?+
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Is MOTS-C intended for human or veterinary use?+
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MOTS-C laboratory reference
MOTS-C is mitochondrial-derived peptide, 16 residues. Handling requirements follow from that chemistry rather than from generic peptide guidance — the pages below cover each aspect specifically for this compound.
Lyophilized and reconstituted storage conditions, plus the practical working window.
Diluent selection, dissolution behaviour, and the calculator preset for this compound.
Which solvents work, why, and what abnormal dissolution behaviour indicates.
The specific chemical routes by which this molecule breaks down, and how to limit each.
Which assays are informative for this molecule, and what to actually check on its COA.
Compound-specific bench practices, and the errors most often made with this molecule.
What to inspect on arrival, and which conditions actually warrant rejecting a vial.
Questions specific to this compound — structure, chemistry, and common misconceptions.
MOTS-C compared with
Reference content is educational laboratory-handling information for in-vitro research use only — not medical advice, not usage guidance, and not a protocol.