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How to Store MOTS-C: Temperature, Shelf Life & Handling

Storage requirements for MOTS-C follow from what the molecule actually is — mitochondrial-derived peptide, 16 residues. The conditions below reflect that chemistry rather than generic peptide guidance.

Mitochondrial-derived peptide, 16 residuesMetabolicCellular Longevity

In plain English

Freezer for the powder, fridge once mixed, two to three weeks, and dark at every stage. This is one of the fussiest compounds here because it contains both of the amino acids that react badly — one with oxygen, one with light. Most molecules have one weakness. This has two.

What MOTS-C actually is

MOTS-c has one of the more surprising origins in this catalogue: its instructions are written not in the DNA of the cell nucleus but inside the separate, much smaller genome carried by mitochondria — the structures that produce most of a cell's energy. It is studied as a signal they send out to the rest of the cell.

Supplied for laboratory research use only — not for human or animal use.

Research-grade MOTS-C

Third-party tested by HPLC and LC-MS, ≥99% purity, with a Certificate of Analysis on every order. Ships across Canada.

Technical detail below

Storage conditions for MOTS-C

Lyophilized powderSealed at -20 °C, dry and dark.
ReconstitutedRefrigerate at 2–8 °C with light protection. Both oxidation-prone residue types are present, so the two main degradation pathways operate simultaneously.
Working windowCommonly worked with for 2–3 weeks at 2–8 °C.
Light exposureProtect from light throughout — tryptophan photo-oxidation applies here as it does to DSIP.

Why these conditions, specifically

MOTS-c is the clearest case in this catalogue for strict oxygen and light control: it carries the two most reactive proteinogenic side chains in a single short sequence.

The main route to be aware of: methionine oxidation to the sulfoxide (+16 Da), and MOTS-c carries methionine at the N-terminus and internally.

All 3 degradation routes for MOTS-C

Freeze–thaw

Aliquot on reconstitution. Each vial opening introduces oxygen that acts on two susceptible residue types at once.

What MOTS-C is studied for

Mitochondrial-derived signalling

Part of a novel class demonstrating that mitochondria encode peptides acting systemically.

AMPK pathway

The most-studied signalling interaction, examined in metabolic and exercise models.

Insulin sensitivity

Investigated in glucose-metabolism research models.

Exercise and longevity biology

Studies have examined MOTS-c expression in relation to physical activity and ageing in animal models.

Summarizes published preclinical literature. Provided for research reference only; not a claim of efficacy or a description of human use.

More MOTS-C reference

Storage reference for other compounds

MOTS-C overview MOTS-C calculatorMOTS-C product details

MOTS-C is supplied strictly as a research chemical for in-vitro laboratory and research use only. It is not intended for human or animal consumption, diagnostic, or therapeutic use. This page is educational laboratory-handling reference information — not medical advice, not usage guidance, and not a protocol.