FOXO4-DRI
FOXO4–p53 interfering D-retro-inverso peptide (FOX04-DRI, Proxofim), freeze-dried. For lab research only.
Molecular reference
Research background
FOXO4-DRI (also written FOX04-DRI, or Proxofim) is the “zombie cell” peptide you may have heard about. It’s designed to interfere with a protein connection that helps old, worn-out cells survive, and it’s one of the most talked-about compounds in ageing research. It’s pricey because it’s built from mirror-image amino acids, which are hard to make. It comes as a freeze-dried powder in a 10 mg vial.
FOXO4-DRI for cellular-senescence research, supplied to Canadian researchers by Popular Peptides. One 10 mg vial, ≥99% purity, CAS 2460055-10-9, molecular weight 5358.2 g/mol. Tested by an independent lab for purity and content (HPLC). Certificates of Analysis (COAs) are for members only. The compound was first described in a 2017 Cell study examining selective apoptosis of senescent cells in cell-culture and mouse models. Ships tracked and insured from Vancouver by Canada Post Xpresspost, usually 1 to 4 business days, with no customs step and no brokerage fee.
Sold as a laboratory research material only, for in vitro use. It isn’t a medicine and isn’t meant for people or animals.
Summarizes published preclinical literature. Provided for research reference only; not a claim of efficacy or a description of human use.
Reconstitution
- Supplied as a lyophilized (freeze-dried) powder for laboratory reconstitution.
- Bacteriostatic water (0.9% benzyl alcohol) is the most common reconstitution solvent for multi-use research handling; sterile or acetic-acid solutions are used for specific compounds.
- Introduce solvent slowly against the vial wall rather than directly onto the powder, and allow it to dissolve without vigorous shaking.
- Use the reconstitution calculator to determine solvent volume for a target concentration in your protocol.
Storage & handling
- Lyophilized powder: store sealed at -20 °C for long-term stability; short periods at 2–8 °C are generally acceptable.
- Once reconstituted: refrigerate at 2–8 °C and protect from light; use within the compound-specific window noted on the COA.
- Avoid repeated freeze–thaw cycles of reconstituted solution.
- Keep away from direct light and heat at all times.
Purity & verification
Third-party tested for HPLC purity and content (≥99% purity). Certificates of Analysis are for members only.
FOXO4-DRI in depth
Lyophilized and reconstituted storage conditions, plus the practical working window.
Diluent selection, dissolution behaviour, and the calculator preset for this compound.
Which solvents work, why, and what abnormal dissolution behaviour indicates.
The specific chemical routes by which this molecule breaks down, and how to limit each.
Which assays are informative for this molecule, and what to actually check on its COA.
Compound-specific bench practices, and the errors most often made with this molecule.
What to inspect on arrival, and which conditions actually warrant rejecting a vial.
Questions specific to this compound — structure, chemistry, and common misconceptions.
Compared with other compounds
Related compounds
FOXO4-DRI is sold strictly as a research chemical for in-vitro laboratory and research use only. It is not intended for human or animal consumption, diagnostic, or therapeutic use. This page is educational reference information, not medical or usage guidance.