How Long Does NAD+ Last? Shelf Life & Stability
"Stable" is meaningless without saying stable against what. NAD+ has its own set of degradation routes, and they determine which storage precautions actually matter for it.
In plain English
The rule that matters most: alkaline conditions break it apart fast. This is the reverse of what several peptides prefer, so do not carry habits across. It also degrades in water faster than peptide solutions do, and light affects it too. Make it fresh when accuracy matters.
What NAD+ actually is
NAD+ is not a peptide, and that single fact governs everything about handling it. It is a coenzyme — think of it as a rechargeable battery that shuttles energy around inside cells. It is present in every living cell, was first identified in 1906, and almost every peptide habit is wrong for it.
Supplied for laboratory research use only — not for human or animal use.
Third-party tested by HPLC and LC-MS, ≥99% purity, with a Certificate of Analysis on every order. Ships across Canada.
Technical detail below
Degradation routes specific to NAD+
- Alkaline hydrolysis — NAD+ degrades rapidly above neutral pH. This is the single most important handling fact about the compound.
- Hydrolysis of the glycosidic bond releasing free nicotinamide, the principal aqueous degradation product.
- Moisture uptake in the dry state, which both initiates degradation and corrupts gravimetric measurement.
- Photo-degradation of the nicotinamide ring.
Do not apply peptide-handling intuitions to NAD+. It is a nucleotide, its degradation chemistry is hydrolytic rather than oxidative or proteolytic, and its pH sensitivity runs the opposite direction to several peptides in this catalogue.
Freeze–thaw tolerance
Aliquot immediately after reconstitution. NAD+ solutions tolerate freezing but each thaw restarts the hydrolytic clock.
How storage addresses these routes
Practical window once reconstituted: Short: commonly worked with within 1–2 weeks at 2–8 °C, and prepared fresh where accuracy matters. Protect from light; the nicotinamide ring is photo-sensitive.
Full NAD+ storage conditionsWhat NAD+ is studied for
Sirtuins consume NAD+ as a co-substrate, which links cellular NAD+ availability directly to their activity.
Its canonical role as the central redox carrier of cellular respiration.
PARP enzymes consume NAD+ during DNA damage response, a heavily studied competing demand.
A major driver of current research interest: measured NAD+ levels fall with age across tissues in animal models.
Summarizes published preclinical literature. Provided for research reference only; not a claim of efficacy or a description of human use.
More NAD+ reference
Lyophilized and reconstituted storage conditions, plus the practical working window.
Diluent selection, dissolution behaviour, and the calculator preset for this compound.
Which solvents work, why, and what abnormal dissolution behaviour indicates.
Which assays are informative for this molecule, and what to actually check on its COA.
Compound-specific bench practices, and the errors most often made with this molecule.
What to inspect on arrival, and which conditions actually warrant rejecting a vial.
Questions specific to this compound — structure, chemistry, and common misconceptions.
Stability reference for other compounds
NAD+ is supplied strictly as a research chemical for in-vitro laboratory and research use only. It is not intended for human or animal consumption, diagnostic, or therapeutic use. This page is educational laboratory-handling reference information — not medical advice, not usage guidance, and not a protocol.