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How to Store NAD+: Temperature, Shelf Life & Handling

Storage requirements for NAD+ follow from what the molecule actually is — dinucleotide coenzyme — not a peptide. The conditions below reflect that chemistry rather than generic peptide guidance.

Dinucleotide coenzyme — not a peptideCellular LongevityMetabolic

In plain English

Freezer, rigorously dry, and use mixed solution within one to two weeks. This powder pulls moisture out of the air more aggressively than anything else here. Open a cold vial and water condenses straight onto the contents within minutes.

What NAD+ actually is

NAD+ is not a peptide, and that single fact governs everything about handling it. It is a coenzyme — think of it as a rechargeable battery that shuttles energy around inside cells. It is present in every living cell, was first identified in 1906, and almost every peptide habit is wrong for it.

Supplied for laboratory research use only — not for human or animal use.

Research-grade NAD+

Third-party tested by HPLC and LC-MS, ≥99% purity, with a Certificate of Analysis on every order. Ships across Canada.

Technical detail below

Storage conditions for NAD+

Lyophilized powderSealed at -20 °C and rigorously dry. NAD+ is strongly hygroscopic — more so than any peptide in this catalogue — and will draw moisture from room air within minutes of a vial being opened cold.
ReconstitutedRefrigerate at 2–8 °C and use promptly. Aqueous NAD+ solutions degrade appreciably faster than peptide solutions of comparable storage conditions.
Working windowShort: commonly worked with within 1–2 weeks at 2–8 °C, and prepared fresh where accuracy matters.
Light exposureProtect from light; the nicotinamide ring is photo-sensitive.

Why these conditions, specifically

Do not apply peptide-handling intuitions to NAD+. It is a nucleotide, its degradation chemistry is hydrolytic rather than oxidative or proteolytic, and its pH sensitivity runs the opposite direction to several peptides in this catalogue.

The main route to be aware of: alkaline hydrolysis — NAD+ degrades rapidly above neutral pH. This is the single most important handling fact about the compound.

All 4 degradation routes for NAD+

Freeze–thaw

Aliquot immediately after reconstitution. NAD+ solutions tolerate freezing but each thaw restarts the hydrolytic clock.

What NAD+ is studied for

Sirtuin activation

Sirtuins consume NAD+ as a co-substrate, which links cellular NAD+ availability directly to their activity.

Mitochondrial energy metabolism

Its canonical role as the central redox carrier of cellular respiration.

DNA repair via PARP

PARP enzymes consume NAD+ during DNA damage response, a heavily studied competing demand.

Age-related NAD+ decline

A major driver of current research interest: measured NAD+ levels fall with age across tissues in animal models.

Summarizes published preclinical literature. Provided for research reference only; not a claim of efficacy or a description of human use.

More NAD+ reference

Storage reference for other compounds

NAD+ overview NAD+ calculatorNAD+ product details

NAD+ is supplied strictly as a research chemical for in-vitro laboratory and research use only. It is not intended for human or animal consumption, diagnostic, or therapeutic use. This page is educational laboratory-handling reference information — not medical advice, not usage guidance, and not a protocol.