5-Amino-1MQ
Small-molecule NNMT inhibitor, powder. For in vitro research use only.
Key facts
- Compound:
- 5-Amino-1MQ
- Purity:
- ≥99%, verified by HPLC
- Identity confirmed by:
- LC-MS, independent third-party lab
- Certificate of analysis:
- available on request, verifiable by lot number
- Ships from:
- Vancouver, BC — typically 2–5 business days, tracked and insured, no customs
- Intended use:
- in vitro laboratory research only — not for human or veterinary consumption
Page last updated
5-Amino-1MQ is a small-molecule NNMT inhibitor, supplied as a powder.
Order 5-Amino-1MQ in Canada with the paperwork to back it. One 50 mg vial, ≥99% purity. Third-party HPLC and LC-MS on every batch, with the batch-specific Certificate of Analysis available on request. Lot-level verification is open to anyone at popularpeptides.ca/verify. Tracked, insured delivery from Vancouver, BC — typically 2 to 5 business days, with no customs step and no brokerage fee.
Supplied lyophilised for in vitro laboratory research use only; not intended for human or veterinary use.
Primary literature
- Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity — Nature, 2014
The knockdown study that established NNMT as a metabolic research target — the rationale for NNMT inhibitors.
Cited for research context. A citation is not a claim that this compound is safe, effective, or approved for any use.
⚠️ Research Use Only. This compound is intended for in vitro research and laboratory use only. Not for human or veterinary consumption.
5-Amino-1MQ — compound background
Small-molecule NNMT inhibitor (methylquinolinium salt) — not a peptide
5-Amino-1MQ is a small quinolinium molecule characterised as a first-in-class inhibitor of NNMT (nicotinamide N-methyltransferase), an enzyme studied at the intersection of adipocyte metabolism and the cellular NAD+/methylation pool. It is not an amino-acid chain, which is why it sits apart from every peptide in this catalogue.
Solubility & reconstitution
As a small, charged quinolinium salt it is freely water-soluble and dissolves cleanly without the acidification, warming or anti-aggregation measures that lyophilized peptides sometimes need. There is no folded structure to denature and no hydrophobic core to drive aggregation.
Readily worked at 10-25 mg/mL; solubility is not the limiting factor.
Storage
Store the sealed powder dry at -20 °C. Small molecules of this class are generally more solution- and temperature-tolerant than peptides. Refrigerate at 2-8 °C. Without proteolysis- or oxidation-prone bonds, the aqueous solution is comparatively stable.
Commonly worked with for several weeks at 2-8 °C in preserved diluent.
Stability
The peptide degradation routes (deamidation, methionine oxidation, aspartate isomerisation) do not apply here. Do not carry peptide-handling intuitions over to this small molecule.
Reading the Certificate of Analysis
Confirm identity by molecular ion (the cation is near 159 Da) and purity by RP-HPLC. Because it is not a peptide, the acetate-salt / net-peptide-content distinction does not apply, but the counterion and any residual synthesis solvents are worth noting on the COA.
Background and handling information is educational, for in-vitro laboratory research use only — not medical advice, dosing, or usage guidance, and not a description of use in humans or animals.
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5-Amino-1MQ laboratory reference
5-Amino-1MQ is small-molecule nnmt inhibitor (methylquinolinium salt) — not a peptide. Handling requirements follow from that chemistry rather than from generic peptide guidance — the pages below cover each aspect specifically for this compound.
Lyophilized and reconstituted storage conditions, plus the practical working window.
Diluent selection, dissolution behaviour, and the calculator preset for this compound.
Which solvents work, why, and what abnormal dissolution behaviour indicates.
The specific chemical routes by which this molecule breaks down, and how to limit each.
Which assays are informative for this molecule, and what to actually check on its COA.
Compound-specific bench practices, and the errors most often made with this molecule.
What to inspect on arrival, and which conditions actually warrant rejecting a vial.
Questions specific to this compound — structure, chemistry, and common misconceptions.
5-Amino-1MQ compared with
Reference content is educational laboratory-handling information for in-vitro research use only — not medical advice, not usage guidance, and not a protocol.