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Research Comparison

5-Amino-1MQ vs CJC-1295 (No DAC)

5-Amino-1MQ and CJC-1295 (No DAC) are studied in overlapping research areas, which is why they are frequently compared. This is a neutral side-by-side reference drawn from published preclinical literature and laboratory handling data.

Shared research areas:Metabolic
ClassSmall-molecule NNMT inhibitor (methylquinolinium salt) — not a peptideGHRH(1-29) tetra-substituted analogue (DAC-free)
Molecular weightNot specified3367.9 g/mol
CAS numberNot assigned / not specifiedNot assigned / not specified
Purity spec≥99%≥99%
Research areasMetabolic, Cellular LongevityHormonal & Endocrine, Metabolic
Primary diluentBacteriostatic water (0.9% benzyl alcohol)Bacteriostatic water (0.9% benzyl alcohol)
Working windowCommonly worked with for several weeks at 2-8 °C in preserved diluent.Commonly worked with for 2-3 weeks at 2-8 °C.
Lead degradation routeMicrobial growth in non-preserved diluent — a container problem rather than a molecular one.Deamidation at Asn/Gln residues over long solution storage.
Freeze–thawTolerant of freeze-thaw — there is no tertiary structure to lose. Aliquoting is still good practice to limit repeated exposure of the stock.Aliquot on first reconstitution; avoid re-freezing the solution.
Light sensitivityNo specific light requirement beyond normal practice.No specific light requirement beyond normal practice.

How they actually differ

Comparing the two: 5-Amino-1MQ is small-molecule nnmt inhibitor (methylquinolinium salt) — not a peptide, while CJC-1295 (No DAC) is ghrh(1-29) tetra-substituted analogue (dac-free) — different molecular classes with different handling consequences; their leading degradation routes differ (microbial growth in non-preserved diluent for 5-Amino-1MQ, deamidation at asn/gln residues over long solution storage. for CJC-1295 (No DAC)), so the storage precautions that matter are not the same; their practical working windows differ once reconstituted. The sections below set out each in full.

5-Amino-1MQ — origin

5-Amino-1MQ is a small quinolinium molecule characterised as a first-in-class inhibitor of NNMT (nicotinamide N-methyltransferase), an enzyme studied at the intersection of adipocyte metabolism and the cellular NAD+/methylation pool. It is not an amino-acid chain, which is why it sits apart from every peptide in this catalogue.

CJC-1295 (No DAC) — origin

CJC-1295 without DAC is the first 29 residues of growth-hormone-releasing hormone carrying four stabilising substitutions (D-Ala2, Gln8, Ala15, Leu27) that resist DPP-4 cleavage. Omitting the Drug Affinity Complex — the albumin-binding element of the DAC version — gives it a short half-life, which is the property researchers study it for.

5-Amino-1MQ research themes

NNMT inhibition

The defining mechanism — preclinical work has examined how blocking NNMT shifts methylation flux and NAD+ salvage in metabolic tissue models.

Adipocyte energy metabolism

Studied in fat-cell models for effects on cellular energy handling and lipid metabolism.

NAD+ economy

Because NNMT consumes a methyl group tied to the NAD+ precursor pool, it is studied alongside the wider NAD+ research field.

CJC-1295 (No DAC) research themes

Pulsatile GH release

Studied for prompting growth-hormone release in short, physiological pulses via the GHRH receptor.

DPP-4 resistance

The four substitutions are studied for extending the molecule beyond the minutes-long survival of native GHRH.

Complementary pairing

Frequently studied alongside ghrelin-receptor secretagogues such as Ipamorelin, which recruit a second GH-release pathway.

5-Amino-1MQ handling

  • Let the sealed vial reach room temperature before opening so moisture does not condense onto the powder.
  • For cell-based assays, prepare a concentrated DMSO stock and dilute into aqueous buffer rather than dissolving directly at high concentration in medium.
  • Label aliquots with reconstitution date and diluent.

CJC-1295 (No DAC) handling

  • Reach room temperature before opening.
  • Swirl to dissolve; do not shake or vortex — foam indicates interfacial stress on the helix.
  • Aliquot and refrigerate; never re-freeze reconstituted solution.

Both third-party tested

Every Popular Peptides batch of 5-Amino-1MQ and CJC-1295 (No DAC) is independently tested by HPLC and LC-MS with a published Certificate of Analysis. Enter a lot number to pull the COA for a specific vial.

Verify a batchPublished COAsHow we test

5-Amino-1MQ reference

Full 5-Amino-1MQ reference 5-Amino-1MQ storage 5-Amino-1MQ reconstitution 5-Amino-1MQ calculator5-Amino-1MQ product details

CJC-1295 (No DAC) reference

Full CJC-1295 (No DAC) reference CJC-1295 (No DAC) storage CJC-1295 (No DAC) reconstitution CJC-1295 (No DAC) calculatorCJC-1295 (No DAC) product details

Related comparisons

5-Amino-1MQ vs CJC-1295 + Ipamorelin5-Amino-1MQ vs DSIP5-Amino-1MQ vs Epitalon5-Amino-1MQ vs GLOW5-Amino-1MQ vs IGF-15-Amino-1MQ vs IGF-1 LR35-Amino-1MQ vs Ipamorelin5-Amino-1MQ vs KGLOW

5-Amino-1MQ and CJC-1295 (No DAC) are supplied strictly as research chemicals for in-vitro laboratory and research use only. They are not intended for human or animal consumption, diagnostic, or therapeutic use. This comparison summarizes published preclinical literature and laboratory handling data; it is not medical advice, not a claim of efficacy, and not usage guidance.