CJC-1295 (No DAC) vs MOTS-C
CJC-1295 (No DAC) and MOTS-C are studied in overlapping research areas, which is why they are frequently compared. This is a neutral side-by-side reference drawn from published preclinical literature and laboratory handling data.
How they actually differ
Comparing the two: CJC-1295 (No DAC) is ghrh(1-29) tetra-substituted analogue (dac-free), while MOTS-C is mitochondrial-derived peptide, 16 residues — different molecular classes with different handling consequences; they call for different primary diluents (bacteriostatic water (0.9% benzyl alcohol) versus sterile or bacteriostatic water); their leading degradation routes differ (deamidation at asn/gln residues over long solution storage. for CJC-1295 (No DAC), methionine oxidation to the sulfoxide (+16 da), and mots-c carries methionine at the n-terminus and internally. for MOTS-C), so the storage precautions that matter are not the same; their practical working windows differ once reconstituted. The sections below set out each in full.
CJC-1295 (No DAC) — origin
CJC-1295 without DAC is the first 29 residues of growth-hormone-releasing hormone carrying four stabilising substitutions (D-Ala2, Gln8, Ala15, Leu27) that resist DPP-4 cleavage. Omitting the Drug Affinity Complex — the albumin-binding element of the DAC version — gives it a short half-life, which is the property researchers study it for.
MOTS-C — origin
MOTS-c is encoded not in nuclear DNA but within the mitochondrial genome — specifically an open reading frame inside the 12S ribosomal RNA gene. Its discovery helped establish that mitochondria encode short signalling peptides that act on the rest of the cell, a genuinely recent addition to cell biology and the reason the compound attracted rapid research interest.
CJC-1295 (No DAC) research themes
Studied for prompting growth-hormone release in short, physiological pulses via the GHRH receptor.
The four substitutions are studied for extending the molecule beyond the minutes-long survival of native GHRH.
Frequently studied alongside ghrelin-receptor secretagogues such as Ipamorelin, which recruit a second GH-release pathway.
MOTS-C research themes
Part of a novel class demonstrating that mitochondria encode peptides acting systemically.
The most-studied signalling interaction, examined in metabolic and exercise models.
Investigated in glucose-metabolism research models.
Studies have examined MOTS-c expression in relation to physical activity and ageing in animal models.
CJC-1295 (No DAC) handling
- Reach room temperature before opening.
- Swirl to dissolve; do not shake or vortex — foam indicates interfacial stress on the helix.
- Aliquot and refrigerate; never re-freeze reconstituted solution.
MOTS-C handling
- Use amber vials or wrap in foil; treat light protection as mandatory rather than precautionary.
- Minimise vial openings — headspace oxygen is the practical driver of oxidation.
- Use low-bind labware for dilute working solutions.
Both third-party tested
Every Popular Peptides batch of CJC-1295 (No DAC) and MOTS-C is independently tested by HPLC and LC-MS with a published Certificate of Analysis. Enter a lot number to pull the COA for a specific vial.
CJC-1295 (No DAC) reference
Related comparisons
CJC-1295 (No DAC) and MOTS-C are supplied strictly as research chemicals for in-vitro laboratory and research use only. They are not intended for human or animal consumption, diagnostic, or therapeutic use. This comparison summarizes published preclinical literature and laboratory handling data; it is not medical advice, not a claim of efficacy, and not usage guidance.