Skip to content
WELCOME10 — 10% OFF YOUR FIRST ORDER  ·  FREE SHIPPING OVER $300 CAD  ·  COA ON EVERY ORDER
Research Comparison

GLP-2/Tirz vs SS-31

GLP-2/Tirz and SS-31 are studied in overlapping research areas, which is why they are frequently compared. This is a neutral side-by-side reference drawn from published preclinical literature and laboratory handling data.

Shared research areas:Metabolic
ClassLipidated dual receptor agonist (GIP / GLP-1), 39-residue chainMitochondria-targeting aromatic-cationic tetrapeptide (cardiolipin-binding)
Molecular weight4813.5 g/mol639.81 g/mol
CAS numberNot assigned / not specifiedNot assigned / not specified
Purity spec≥99%≥99%
Research areasMetabolicCellular Longevity, Metabolic
Primary diluentBacteriostatic water (0.9% benzyl alcohol)Bacteriostatic water (0.9% benzyl alcohol)
Working windowCommonly worked with for 4–6 weeks at 2–8 °C.Commonly worked with for 3-4 weeks at 2-8 °C.
Lead degradation routeInterfacial aggregation from agitation or freezing — the dominant practical route.Adsorptive loss to plasticware from the cationic charge — the main practical concern.
Freeze–thawDo not freeze reconstituted solution. Interfacial aggregation during freezing is the characteristic failure mode and is irreversible.Tolerant; the unnatural residues resist degradation. Aliquot as standard practice.
Light sensitivityNo specific light requirement beyond normal practice.No specific light requirement beyond normal practice.

How they actually differ

Comparing the two: GLP-2/Tirz is lipidated dual receptor agonist (gip / glp-1), 39-residue chain, while SS-31 is mitochondria-targeting aromatic-cationic tetrapeptide (cardiolipin-binding) — different molecular classes with different handling consequences; their leading degradation routes differ (interfacial aggregation from agitation or freezing for GLP-2/Tirz, adsorptive loss to plasticware from the cationic charge for SS-31), so the storage precautions that matter are not the same; their practical working windows differ once reconstituted. The sections below set out each in full.

GLP-2/Tirz — origin

GLP-2/Tirz is built on a GIP-based backbone rather than a GLP-1 one — an important and often-missed design detail. It was engineered from the GIP sequence and modified to acquire GLP-1 receptor activity, with a C20 fatty diacid attached via a linker for albumin binding. The term "twincretin" describes the dual incretin activity.

SS-31 — origin

SS-31 (Elamipretide) is a Szeto-Schiller aromatic-cationic tetrapeptide (D-Arg-2',6'-dimethyltyrosine-Lys-Phe-NH2) that concentrates in the inner mitochondrial membrane and binds cardiolipin, the lipid unique to that membrane. Its structure is the reason it is studied specifically at the mitochondrion rather than as a general antioxidant.

GLP-2/Tirz research themes

Dual incretin engagement

Simultaneous GIP and GLP-1 receptor activity from a GIP-derived backbone.

Insulin secretion and glucagon suppression

Core metabolic research endpoints for the incretin class.

Gastric emptying

A well-characterised GLP-1 pathway effect studied in metabolic models.

GIP receptor pharmacology

Whether GIP agonism or antagonism is the productive direction remains an active research debate.

SS-31 research themes

Cardiolipin binding

Studied for selective association with cardiolipin in the inner mitochondrial membrane, the basis of its mitochondrial targeting.

Electron transport efficiency

Examined for effects on mitochondrial energy production in research models of mitochondrial dysfunction.

Oxidative stress

Investigated around reactive-oxygen-species handling at the mitochondrion.

GLP-2/Tirz handling

  • Swirl, never shake or vortex.
  • Add diluent down the vial wall and give the cake time — several minutes of slow dissolution is normal, not a defect.
  • Store upright and refrigerated; do not freeze once reconstituted.

SS-31 handling

  • Reach room temperature before opening.
  • Use low-bind labware and buffers at low working concentrations to limit adsorption of the cationic peptide.
  • Aliquot and refrigerate.

Both third-party tested

Every Popular Peptides batch of GLP-2/Tirz and SS-31 is independently tested by HPLC and LC-MS with a published Certificate of Analysis. Enter a lot number to pull the COA for a specific vial.

Verify a batchPublished COAsHow we test

GLP-2/Tirz reference

Full GLP-2/Tirz reference GLP-2/Tirz storage GLP-2/Tirz reconstitution GLP-2/Tirz calculatorGLP-2/Tirz product details

SS-31 reference

Full SS-31 reference SS-31 storage SS-31 reconstitution SS-31 calculatorSS-31 product details

Related comparisons

5-Amino-1MQ vs GLP-2/Tirz5-Amino-1MQ vs SS-31CJC-1295 (No DAC) vs GLP-2/TirzCJC-1295 (No DAC) vs SS-31CJC-1295 + Ipamorelin vs GLP-2/TirzCJC-1295 + Ipamorelin vs SS-31DSIP vs SS-31Epitalon vs SS-31

GLP-2/Tirz and SS-31 are supplied strictly as research chemicals for in-vitro laboratory and research use only. They are not intended for human or animal consumption, diagnostic, or therapeutic use. This comparison summarizes published preclinical literature and laboratory handling data; it is not medical advice, not a claim of efficacy, and not usage guidance.