GLP-2/Tirz
Synthetic dual-incretin research peptide, lyophilised. For in vitro research use only.
Key facts
- Compound:
- GLP-2/Tirz
- Purity:
- ≥99%, verified by HPLC
- Identity confirmed by:
- LC-MS, independent third-party lab
- Molecular weight:
- 4813.5 g/mol
- Certificate of analysis:
- available on request, verifiable by lot number
- Ships from:
- Vancouver, BC — typically 2–5 business days, tracked and insured, no customs
- Intended use:
- in vitro laboratory research only — not for human or veterinary consumption
Page last updated
GLP-2/Tirz is a synthetic dual-incretin peptide.
Order GLP-2/Tirz in Canada with the paperwork to back it. ≥99% purity, molecular weight 4813.5 g/mol. Third-party HPLC and LC-MS on every batch, with the batch-specific Certificate of Analysis available on request. Lot-level verification is open to anyone at popularpeptides.ca/verify. Tracked, insured delivery from Vancouver, BC — typically 2 to 5 business days, with no customs step and no brokerage fee.
Supplied lyophilised for in vitro laboratory research use only; not intended for human or veterinary use.
Primary literature
- Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1) — New England Journal of Medicine, 2022
The dual GIP/GLP-1 agonist’s pivotal obesity trial, 2,539 participants over 72 weeks.
- Tirzepatide as Compared with Semaglutide for the Treatment of Obesity (SURMOUNT-5) — New England Journal of Medicine, 2025
The first head-to-head trial against semaglutide, 751 participants.
Cited for research context. A citation is not a claim that this compound is safe, effective, or approved for any use.
⚠️ Research Use Only. This compound is intended for in vitro research and laboratory use only. Not for human or veterinary consumption.
GLP-2/Tirz — compound background
Lipidated dual receptor agonist (GIP / GLP-1), 39-residue chain
GLP-2/Tirz is built on a GIP-based backbone rather than a GLP-1 one — an important and often-missed design detail. It was engineered from the GIP sequence and modified to acquire GLP-1 receptor activity, with a C20 fatty diacid attached via a linker for albumin binding. The term "twincretin" describes the dual incretin activity.
Solubility & reconstitution
Dissolves well but shares the amphiphilic behaviour of all lipidated peptides — prone to foaming, self-associating at higher concentrations. Allow several minutes of gentle swirling rather than forcing dissolution.
Commonly worked at 5–10 mg/mL.
Storage
Sealed at -20 °C. Robust as dry powder. Refrigerate at 2–8 °C. The albumin-binding modification confers good solution stability.
Commonly worked with for 4–6 weeks at 2–8 °C.
Stability
Do not freeze reconstituted solution. Interfacial aggregation during freezing is the characteristic failure mode and is irreversible.
Reading the Certificate of Analysis
Confirm the mass near 4813.5 Da. As with GLP-3/RT, aggregate content is the check that RP-HPLC purity alone will not give you. For a 39-residue synthesis, also review the chromatogram for closely eluting deletion sequences.
Background and handling information is educational, for in-vitro laboratory research use only — not medical advice, dosing, or usage guidance, and not a description of use in humans or animals.
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GLP-2/Tirz laboratory reference
GLP-2/Tirz is lipidated dual receptor agonist (gip / glp-1), 39-residue chain. Handling requirements follow from that chemistry rather than from generic peptide guidance — the pages below cover each aspect specifically for this compound.
Lyophilized and reconstituted storage conditions, plus the practical working window.
Diluent selection, dissolution behaviour, and the calculator preset for this compound.
Which solvents work, why, and what abnormal dissolution behaviour indicates.
The specific chemical routes by which this molecule breaks down, and how to limit each.
Which assays are informative for this molecule, and what to actually check on its COA.
Compound-specific bench practices, and the errors most often made with this molecule.
What to inspect on arrival, and which conditions actually warrant rejecting a vial.
Questions specific to this compound — structure, chemistry, and common misconceptions.
GLP-2/Tirz compared with
Reference content is educational laboratory-handling information for in-vitro research use only — not medical advice, not usage guidance, and not a protocol.