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Research Comparison

ARA 290 vs KPV

ARA 290 and KPV are studied in overlapping research areas, which is why they are frequently compared. This is a neutral side-by-side reference drawn from published preclinical literature and laboratory handling data.

Shared research areas:Tissue Regeneration
Class11-amino-acid EPO-derived linear peptideTripeptide (Lys-Pro-Val), alpha-MSH C-terminal fragment
Molecular weight1257.4 g/mol342.4 g/mol
CAS numberNot assigned / not specifiedNot assigned / not specified
Purity spec≥99%≥99%
Research areasTissue Regeneration, Cognitive & NeurologicalGastrointestinal, Tissue Regeneration
Primary diluentBacteriostatic water (0.9% benzyl alcohol)Bacteriostatic water (0.9% benzyl alcohol)
Working windowCommonly worked with for 2-4 weeks at 2-8 °C in bacteriostatic water.Commonly worked with for 3-4 weeks at 2-8 °C.
Lead degradation routeAsparagine/glutamine deamidation is the most plausible slow route for this sequence.Adsorptive loss to plasticware at very low working concentrations — the main practical concern for such a small molecule.
Freeze–thawAliquot on first reconstitution; the short backbone tolerates a freeze better than folded proteins but repeated cycles still concentrate solutes at the ice interface.Very tolerant; a tripeptide has no structure to disrupt. Aliquot to limit repeated handling.
Light sensitivityNo specific light requirement beyond normal practice.No specific light requirement beyond normal practice.

How they actually differ

Comparing the two: ARA 290 is 11-amino-acid epo-derived linear peptide, while KPV is tripeptide (lys-pro-val), alpha-msh c-terminal fragment — different molecular classes with different handling consequences; their leading degradation routes differ (asparagine/glutamine deamidation is the most plausible slow route for this sequence. for ARA 290, adsorptive loss to plasticware at very low working concentrations for KPV), so the storage precautions that matter are not the same; their practical working windows differ once reconstituted. The sections below set out each in full.

ARA 290 — origin

ARA 290 (Cibinetide) is an 11-residue peptide modelled on the helix-B surface of erythropoietin. It was engineered to engage the innate repair receptor — a heteromer of the EPO receptor and the beta-common receptor — without the erythropoietic (red-blood-cell-stimulating) activity of full-length EPO.

KPV — origin

KPV is the three-residue C-terminal tail of alpha-melanocyte-stimulating hormone. It retains the anti-inflammatory character associated with the parent hormone while lacking the melanocortin-receptor region responsible for pigmentation — the reason it is studied for inflammation without a tanning effect.

ARA 290 research themes

Innate repair receptor

Studied for selective engagement of the EPOR/beta-common receptor heteromer that mediates tissue-protective signalling, distinct from the classical erythropoietic receptor.

Neuropathic pain models

A substantial share of the published literature examines small-fibre and neuropathic-pain research models.

Anti-inflammatory signalling

Investigated for modulation of inflammatory pathways in preclinical tissue-injury models.

KPV research themes

Anti-inflammatory signalling

Studied for modulation of inflammatory pathways such as NF-kB in cell and tissue models, inherited from the alpha-MSH parent.

Gastrointestinal models

A significant share of the literature examines gut-inflammation research models.

Skin and tissue

Investigated in dermal and tissue-repair contexts without the pigmentation activity of the full hormone.

ARA 290 handling

  • Reach room temperature before opening the vial.
  • Add diluent gently down the vial wall; do not vortex.
  • Use low-bind labware at low working concentrations to limit adsorption.

KPV handling

  • Reach room temperature before opening.
  • Use low-bind labware at very low working concentrations to limit adsorption.
  • Label aliquots with reconstitution date and diluent.

Both third-party tested

Every Popular Peptides batch of ARA 290 and KPV is independently tested by HPLC and LC-MS with a published Certificate of Analysis. Enter a lot number to pull the COA for a specific vial.

Verify a batchPublished COAsHow we test

ARA 290 reference

Full ARA 290 reference ARA 290 storage ARA 290 reconstitution ARA 290 calculatorARA 290 product details

KPV reference

Full KPV reference KPV storage KPV reconstitution KPV calculatorKPV product details

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ARA 290 and KPV are supplied strictly as research chemicals for in-vitro laboratory and research use only. They are not intended for human or animal consumption, diagnostic, or therapeutic use. This comparison summarizes published preclinical literature and laboratory handling data; it is not medical advice, not a claim of efficacy, and not usage guidance.