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Research Comparison

ARA 290 vs Oxytocin Acetate

ARA 290 and Oxytocin Acetate are studied in overlapping research areas, which is why they are frequently compared. This is a neutral side-by-side reference drawn from published preclinical literature and laboratory handling data.

Shared research areas:Cognitive & Neurological
Class11-amino-acid EPO-derived linear peptideCyclic nonapeptide with intramolecular disulfide bridge
Molecular weight1257.4 g/mol1007.19 g/mol
CAS numberNot assigned / not specified50-56-6
Purity spec≥99%≥99%
Research areasTissue Regeneration, Cognitive & NeurologicalCognitive & Neurological
Primary diluentBacteriostatic water (0.9% benzyl alcohol)Sterile or bacteriostatic water
Working windowCommonly worked with for 2-4 weeks at 2-8 °C in bacteriostatic water.Shorter than most: commonly worked with within 1–2 weeks at 2–8 °C.
Lead degradation routeAsparagine/glutamine deamidation is the most plausible slow route for this sequence.Disulfide exchange and intermolecular dimerisation — the dominant and best-characterised degradation route for oxytocin in solution.
Freeze–thawAliquot on first reconstitution; the short backbone tolerates a freeze better than folded proteins but repeated cycles still concentrate solutes at the ice interface.Aliquot immediately. Freeze–thaw cycling is a particular problem here because interfacial stress promotes the dimerisation route.
Light sensitivityNo specific light requirement beyond normal practice.Protect from light and avoid elevated temperature, both of which accelerate disulfide exchange.

How they actually differ

Comparing the two: ARA 290 is 11-amino-acid epo-derived linear peptide, while Oxytocin Acetate is cyclic nonapeptide with intramolecular disulfide bridge — different molecular classes with different handling consequences; they call for different primary diluents (bacteriostatic water (0.9% benzyl alcohol) versus sterile or bacteriostatic water); their leading degradation routes differ (asparagine/glutamine deamidation is the most plausible slow route for this sequence. for ARA 290, disulfide exchange and intermolecular dimerisation for Oxytocin Acetate), so the storage precautions that matter are not the same; their practical working windows differ once reconstituted. The sections below set out each in full.

ARA 290 — origin

ARA 290 (Cibinetide) is an 11-residue peptide modelled on the helix-B surface of erythropoietin. It was engineered to engage the innate repair receptor — a heteromer of the EPO receptor and the beta-common receptor — without the erythropoietic (red-blood-cell-stimulating) activity of full-length EPO.

Oxytocin Acetate — origin

Oxytocin was the first peptide hormone to be chemically synthesised, by Vincent du Vigneaud in 1953 — work that won the 1955 Nobel Prize in Chemistry and effectively founded the field of peptide synthesis. Every compound in this catalogue is downstream of that achievement.

ARA 290 research themes

Innate repair receptor

Studied for selective engagement of the EPOR/beta-common receptor heteromer that mediates tissue-protective signalling, distinct from the classical erythropoietic receptor.

Neuropathic pain models

A substantial share of the published literature examines small-fibre and neuropathic-pain research models.

Anti-inflammatory signalling

Investigated for modulation of inflammatory pathways in preclinical tissue-injury models.

Oxytocin Acetate research themes

Social behaviour and bonding

The largest behavioural-neuroscience literature of any peptide in this catalogue.

HPA axis and stress modulation

Studied for interactions with cortisol and stress-response signalling.

Reproductive physiology

Its originally characterised role, and the basis of its clinical history.

Vasopressin receptor cross-talk

Oxytocin and vasopressin differ by two residues, and receptor cross-reactivity is a persistent methodological theme.

ARA 290 handling

  • Reach room temperature before opening the vial.
  • Add diluent gently down the vial wall; do not vortex.
  • Use low-bind labware at low working concentrations to limit adsorption.

Oxytocin Acetate handling

  • Do not store reconstituted oxytocin at alkaline pH — beta-elimination of the disulfide is irreversible.
  • Avoid vigorous agitation and foaming; interfacial stress drives both aggregation and disulfide scrambling.
  • Keep reducing agents well away from the workflow — any thiol will open the ring.
  • Aliquot on the day of reconstitution rather than repeatedly sampling one vial.

Both third-party tested

Every Popular Peptides batch of ARA 290 and Oxytocin Acetate is independently tested by HPLC and LC-MS with a published Certificate of Analysis. Enter a lot number to pull the COA for a specific vial.

Verify a batchPublished COAsHow we test

ARA 290 reference

Full ARA 290 reference ARA 290 storage ARA 290 reconstitution ARA 290 calculatorARA 290 product details

Oxytocin Acetate reference

Full Oxytocin Acetate reference Oxytocin Acetate storage Oxytocin Acetate reconstitution Oxytocin Acetate calculatorOxytocin Acetate product details

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ARA 290 and Oxytocin Acetate are supplied strictly as research chemicals for in-vitro laboratory and research use only. They are not intended for human or animal consumption, diagnostic, or therapeutic use. This comparison summarizes published preclinical literature and laboratory handling data; it is not medical advice, not a claim of efficacy, and not usage guidance.