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Research Comparison

ARA 290 vs Selank

ARA 290 and Selank are studied in overlapping research areas, which is why they are frequently compared. This is a neutral side-by-side reference drawn from published preclinical literature and laboratory handling data.

Shared research areas:Cognitive & Neurological
Class11-amino-acid EPO-derived linear peptideSynthetic heptapeptide, tuftsin analogue
Molecular weight1257.4 g/mol751.86 g/mol
CAS numberNot assigned / not specified129954-34-3
Purity spec≥99%≥99%
Research areasTissue Regeneration, Cognitive & NeurologicalCognitive & Neurological
Primary diluentBacteriostatic water (0.9% benzyl alcohol)Sterile or bacteriostatic water
Working windowCommonly worked with for 2-4 weeks at 2-8 °C in bacteriostatic water.Commonly worked with for 3–4 weeks at 2–8 °C — a longer window than most peptides of comparable size, precisely because it lacks oxidisable residues.
Lead degradation routeAsparagine/glutamine deamidation is the most plausible slow route for this sequence.Adsorption to glass and untreated plastic — the practically significant loss route for this cationic peptide at low concentration, not a chemical degradation at all.
Freeze–thawAliquot on first reconstitution; the short backbone tolerates a freeze better than folded proteins but repeated cycles still concentrate solutes at the ice interface.Tolerant, but aliquoting is still the correct default for a multi-week study.
Light sensitivityNo specific light requirement beyond normal practice.No specific light requirement beyond normal practice.

How they actually differ

Comparing the two: ARA 290 is 11-amino-acid epo-derived linear peptide, while Selank is synthetic heptapeptide, tuftsin analogue — different molecular classes with different handling consequences; they call for different primary diluents (bacteriostatic water (0.9% benzyl alcohol) versus sterile or bacteriostatic water); their leading degradation routes differ (asparagine/glutamine deamidation is the most plausible slow route for this sequence. for ARA 290, adsorption to glass and untreated plastic for Selank), so the storage precautions that matter are not the same; their practical working windows differ once reconstituted. The sections below set out each in full.

ARA 290 — origin

ARA 290 (Cibinetide) is an 11-residue peptide modelled on the helix-B surface of erythropoietin. It was engineered to engage the innate repair receptor — a heteromer of the EPO receptor and the beta-common receptor — without the erythropoietic (red-blood-cell-stimulating) activity of full-length EPO.

Selank — origin

Selank was developed at the Institute of Molecular Genetics in Moscow by extending the immunomodulatory tetrapeptide tuftsin (Thr-Lys-Pro-Arg) with the same Pro-Gly-Pro stabilising motif used in Semax. It is, in effect, the anxiolytic-research counterpart to Semax from the same design programme.

ARA 290 research themes

Innate repair receptor

Studied for selective engagement of the EPOR/beta-common receptor heteromer that mediates tissue-protective signalling, distinct from the classical erythropoietic receptor.

Neuropathic pain models

A substantial share of the published literature examines small-fibre and neuropathic-pain research models.

Anti-inflammatory signalling

Investigated for modulation of inflammatory pathways in preclinical tissue-injury models.

Selank research themes

Anxiolytic models

The most-populated area of the Selank literature, examined in behavioural anxiety models.

GABAergic and serotonergic modulation

Studies have investigated interaction with both systems without the sedative profile of classical anxiolytics.

Tuftsin lineage and immune signalling

Its parent tetrapeptide is immunomodulatory, and some research follows that thread.

Memory consolidation

Investigated in learning and memory paradigms alongside its stress-response work.

ARA 290 handling

  • Reach room temperature before opening the vial.
  • Add diluent gently down the vial wall; do not vortex.
  • Use low-bind labware at low working concentrations to limit adsorption.

Selank handling

  • Use low-bind tubes and pipette tips for dilute working solutions; the strong positive charge promotes surface adsorption.
  • Avoid unnecessary transfers between containers — each one is an opportunity for adsorptive loss.
  • Standard refrigerated storage is sufficient; elaborate light protection is not required for this sequence.

Both third-party tested

Every Popular Peptides batch of ARA 290 and Selank is independently tested by HPLC and LC-MS with a published Certificate of Analysis. Enter a lot number to pull the COA for a specific vial.

Verify a batchPublished COAsHow we test

ARA 290 reference

Full ARA 290 reference ARA 290 storage ARA 290 reconstitution ARA 290 calculatorARA 290 product details

Selank reference

Full Selank reference Selank storage Selank reconstitution Selank calculatorSelank product details

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ARA 290 and Selank are supplied strictly as research chemicals for in-vitro laboratory and research use only. They are not intended for human or animal consumption, diagnostic, or therapeutic use. This comparison summarizes published preclinical literature and laboratory handling data; it is not medical advice, not a claim of efficacy, and not usage guidance.