NAD+ in Canada: Anti-Aging Fuel or Spa Menu?
Kobi Williams · Popular Peptides Canada ·
NAD+ is a coenzyme, not a peptide, and its levels fall with age. Most human trials test oral precursors rather than NAD+ itself: in 2018, nicotinamide riboside (NR) raised blood NAD+ in healthy older adults, and in 2021 nicotinamide mononucleotide (NMN) improved muscle insulin sensitivity in about two dozen women with prediabetes. There is very little controlled research on IV NAD+. Injectable NAD+ is not approved as a medicine in Canada and is named in Health Canada’s April 2026 advisory.
Real biology, small precursor trials. The drip is mostly untested.
Scores = our read of the published studies, not medical advice.
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Full transcript
[0:00]NAD+ drips are sold as anti-aging fuel. But what do the human studies actually test? Let’s check.
[0:06]First, NAD+ isn’t a peptide. It’s a coenzyme, a helper molecule every cell uses to make energy. It’s in peptide shops the way a cousin shows up at the family reunion. Studies show NAD+ levels drop as we age. That part is real.
[0:17]Here’s the twist. Most human trials don’t use NAD+. They use precursors, the building blocks, taken by mouth. In 2018, one called NR raised NAD+ in the blood of healthy older adults. In 2021, another called NMN improved muscle insulin sensitivity in about two dozen women with prediabetes.
[0:34]And NAD+ itself, straight into a vein? In people? There’s very little controlled research. Small studies, short follow-up, not much else.
[0:43]Injectable NAD+ isn’t approved as a medicine in Canada, and it’s named in Health Canada’s April 2026 warning about peptides sold online. So: the biology is real, the precursor trials are small, and the drip is mostly untested. Read the studies, not the spa menu.
Read the studies
- NAD+ metabolism and its roles in cellular processes during ageing (Covarrubias et al.)Nature Reviews Molecular Cell Biology, 2021
- Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults (Martens et al.)Nature Communications, 2018
- Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women (Yoshino et al.)Science, 2021
- Think twice before injecting peptides bought online: unauthorized products can seriously harm your healthHealth Canada advisory, April 9, 2026
From $59.99 · ships from Vancouver · for in vitro laboratory research only
Read more about NAD+
- NAD+: Mitochondrial Health and Cellular Longevity Research
NAD+ is a central coenzyme in cellular energy metabolism and has emerged as a key research target in aging biology, DNA repair, and sirtuin activation.
- NAD+ Nasal Spray: A Research Overview of the Cellular Longevity Coenzyme
NAD+ supplementation research has exploded in the last decade. The nasal spray delivery format is adding a new dimension to how researchers study this critical cellular coenzyme.
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All Popular Peptides products are supplied for in vitro laboratory research use only and are not for human or veterinary consumption. Nothing in this video or on this page is medical advice.