How to Reconstitute DSIP: A Step-by-Step Guide
Reconstituting DSIP is not identical to reconstituting any other compound in this library. Water-soluble, but distinctly more acidic than the other short peptides here: two acidic residues (Asp, Glu) and no basic residues give it a low isoelectric point.
In plain English
Dissolves in water without trouble, but keep it out of the light while you work. One quirk: this molecule is acidic in character, so keep your liquid at neutral or slightly alkaline. Pushing it acidic risks the material dropping out of solution.
What DSIP actually is
DSIP stands for Delta Sleep-Inducing Peptide. It was isolated in the 1970s from the blood of animals in deep sleep — its name records how it was discovered, not a settled explanation of what it does. Decades on, researchers still have not agreed on its mechanism.
Supplied for laboratory research use only — not for human or animal use.
Third-party tested by HPLC and LC-MS, ≥99% purity, with a Certificate of Analysis on every order. Ships across Canada.
Technical detail below
Diluent selection for DSIP
Water-soluble, but distinctly more acidic than the other short peptides here: two acidic residues (Asp, Glu) and no basic residues give it a low isoelectric point. Solubility is therefore good at neutral and alkaline pH and drops as the solution approaches the pI in the acidic range — the opposite pH behaviour to cationic peptides like Selank.
Common reconstitution reference
A 10 mg vial in 2 mL gives 5 mg/mL. Keep the reconstituted vial protected from light throughout.
Open the DSIP calculatorMethod notes for this compound
- Store and handle protected from light at all stages, including during reconstitution.
- Keep working solutions at or above neutral pH; acidification risks precipitation near the isoelectric point.
- Avoid prolonged storage of reconstituted material — the isomerisation route is slow but cumulative.
What DSIP is studied for
Investigated for effects on slow-wave sleep in the models that gave the peptide its name.
Studies have examined interactions with stress-axis signalling.
Explored in preclinical models of oxidative and stress-related neuronal injury.
Notably, decades of work have not converged on an accepted receptor or mechanism — a recurring theme in the literature.
Summarizes published preclinical literature. Provided for research reference only; not a claim of efficacy or a description of human use.
More DSIP reference
Lyophilized and reconstituted storage conditions, plus the practical working window.
Which solvents work, why, and what abnormal dissolution behaviour indicates.
The specific chemical routes by which this molecule breaks down, and how to limit each.
Which assays are informative for this molecule, and what to actually check on its COA.
Compound-specific bench practices, and the errors most often made with this molecule.
What to inspect on arrival, and which conditions actually warrant rejecting a vial.
Questions specific to this compound — structure, chemistry, and common misconceptions.
Reconstitution reference for other compounds
DSIP is supplied strictly as a research chemical for in-vitro laboratory and research use only. It is not intended for human or animal consumption, diagnostic, or therapeutic use. This page is educational laboratory-handling reference information — not medical advice, not usage guidance, and not a protocol.