DSIP
Synthetic nonapeptide (DSIP), lyophilised. For in vitro research use only.
Key facts
- Compound:
- DSIP
- Purity:
- ≥99%, verified by HPLC
- Identity confirmed by:
- LC-MS, independent third-party lab
- Molecular weight:
- 848.94 g/mol
- Certificate of analysis:
- available on request, verifiable by lot number
- Ships from:
- Vancouver, BC — typically 2–5 business days, tracked and insured, no customs
- Intended use:
- in vitro laboratory research only — not for human or veterinary consumption
Page last updated
DSIP (delta sleep-inducing peptide) is a synthetic nonapeptide.
DSIP, supplied to Canadian researchers by Popular Peptides. Available in 10 mg and 5 mg, ≥99% purity, molecular weight 848.94 g/mol. Independently tested by HPLC and LC-MS; the batch-specific Certificate of Analysis is available on request. The lot number on the vial can be checked at popularpeptides.ca/verify. Ships tracked and insured from Vancouver in 2 to 5 business days, with no customs step and no brokerage fee.
Supplied lyophilised for in vitro laboratory research use only; not intended for human or veterinary use.
⚠️ Research Use Only. This compound is intended for in vitro research and laboratory use only. Not for human or veterinary consumption.
DSIP — compound background
Nonapeptide (9 residues), strongly acidic
DSIP was isolated in the 1970s from the cerebral venous blood of rabbits in slow-wave sleep, in one of the more unusual isolation efforts in neuropeptide research. The name records the assay it was found by rather than a settled mechanism — its physiological role remains debated in the literature.
Solubility & reconstitution
Water-soluble, but distinctly more acidic than the other short peptides here: two acidic residues (Asp, Glu) and no basic residues give it a low isoelectric point. Solubility is therefore good at neutral and alkaline pH and drops as the solution approaches the pI in the acidic range — the opposite pH behaviour to cationic peptides like Selank.
Storage
Sealed at -20 °C. Keep dry; the acidic lyophilizate is hygroscopic. Refrigerate at 2–8 °C, protected from light on account of the N-terminal tryptophan.
Commonly worked with for 2–3 weeks at 2–8 °C.
Stability
DSIP combines two independent liabilities — a photo-labile N-terminal residue and an Asp-Ala isomerisation site. It rewards careful storage more than most short peptides.
Reading the Certificate of Analysis
Confirm the molecular ion near 848.9 Da. Watch for isomerised species, which are isobaric with the parent (identical mass) and therefore invisible to mass spectrometry — they show only as additional or broadened RP-HPLC peaks. This is a case where the chromatogram is more informative than the mass spectrum.
Background and handling information is educational, for in-vitro laboratory research use only — not medical advice, dosing, or usage guidance, and not a description of use in humans or animals.
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DSIP laboratory reference
DSIP is nonapeptide (9 residues), strongly acidic. Handling requirements follow from that chemistry rather than from generic peptide guidance — the pages below cover each aspect specifically for this compound.
Lyophilized and reconstituted storage conditions, plus the practical working window.
Diluent selection, dissolution behaviour, and the calculator preset for this compound.
Which solvents work, why, and what abnormal dissolution behaviour indicates.
The specific chemical routes by which this molecule breaks down, and how to limit each.
Which assays are informative for this molecule, and what to actually check on its COA.
Compound-specific bench practices, and the errors most often made with this molecule.
What to inspect on arrival, and which conditions actually warrant rejecting a vial.
Questions specific to this compound — structure, chemistry, and common misconceptions.
Reference content is educational laboratory-handling information for in-vitro research use only — not medical advice, not usage guidance, and not a protocol.