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Research Comparison

CJC-1295 (No DAC) vs Kisspeptin

CJC-1295 (No DAC) and Kisspeptin are studied in overlapping research areas, which is why they are frequently compared. This is a neutral side-by-side reference drawn from published preclinical literature and laboratory handling data.

Shared research areas:Hormonal & Endocrine
ClassGHRH(1-29) tetra-substituted analogue (DAC-free)Decapeptide (Kisspeptin-10), KISS1 gene product fragment
Molecular weight3367.9 g/mol1302.5 g/mol
CAS numberNot assigned / not specifiedNot assigned / not specified
Purity spec≥99%≥99%
Research areasHormonal & Endocrine, MetabolicReproductive, Hormonal & Endocrine
Primary diluentBacteriostatic water (0.9% benzyl alcohol)Bacteriostatic water (0.9% benzyl alcohol)
Working windowCommonly worked with for 2-3 weeks at 2-8 °C.Commonly worked with for 2-3 weeks at 2-8 °C, shorter if exposed to light.
Lead degradation routeDeamidation at Asn/Gln residues over long solution storage.Tryptophan oxidation, accelerated by light — the characteristic route for this sequence.
Freeze–thawAliquot on first reconstitution; avoid re-freezing the solution.Aliquot on first reconstitution; avoid repeated cycles.
Light sensitivityNo specific light requirement beyond normal practice.Contains tryptophan — keep reconstituted solution out of direct light.

How they actually differ

Comparing the two: CJC-1295 (No DAC) is ghrh(1-29) tetra-substituted analogue (dac-free), while Kisspeptin is decapeptide (kisspeptin-10), kiss1 gene product fragment — different molecular classes with different handling consequences; their leading degradation routes differ (deamidation at asn/gln residues over long solution storage. for CJC-1295 (No DAC), tryptophan oxidation, accelerated by light for Kisspeptin), so the storage precautions that matter are not the same; their practical working windows differ once reconstituted. The sections below set out each in full.

CJC-1295 (No DAC) — origin

CJC-1295 without DAC is the first 29 residues of growth-hormone-releasing hormone carrying four stabilising substitutions (D-Ala2, Gln8, Ala15, Leu27) that resist DPP-4 cleavage. Omitting the Drug Affinity Complex — the albumin-binding element of the DAC version — gives it a short half-life, which is the property researchers study it for.

Kisspeptin — origin

Kisspeptin-10 is the C-terminal decapeptide of the KISS1 gene product, active at the KISS1 receptor (GPR54). It sits at the top of the reproductive signalling axis, studied for triggering GnRH release. The parent protein was first described as a metastasis suppressor, hence the older name metastin.

CJC-1295 (No DAC) research themes

Pulsatile GH release

Studied for prompting growth-hormone release in short, physiological pulses via the GHRH receptor.

DPP-4 resistance

The four substitutions are studied for extending the molecule beyond the minutes-long survival of native GHRH.

Complementary pairing

Frequently studied alongside ghrelin-receptor secretagogues such as Ipamorelin, which recruit a second GH-release pathway.

Kisspeptin research themes

Reproductive axis

Studied as the upstream trigger of GnRH release and the downstream LH and FSH signalling cascade.

KISS1R / GPR54 signalling

Examined as the endogenous ligand for the KISS1 receptor in reproductive neuroendocrine models.

Metastasis-suppressor origin

The parent KISS1 product was first characterised in cancer-metastasis research, a separate strand of the literature.

CJC-1295 (No DAC) handling

  • Reach room temperature before opening.
  • Swirl to dissolve; do not shake or vortex — foam indicates interfacial stress on the helix.
  • Aliquot and refrigerate; never re-freeze reconstituted solution.

Kisspeptin handling

  • Reach room temperature before opening.
  • Keep reconstituted solution out of direct light during long bench sessions.
  • Aliquot and refrigerate.

Both third-party tested

Every Popular Peptides batch of CJC-1295 (No DAC) and Kisspeptin is independently tested by HPLC and LC-MS with a published Certificate of Analysis. Enter a lot number to pull the COA for a specific vial.

Verify a batchPublished COAsHow we test

CJC-1295 (No DAC) reference

Full CJC-1295 (No DAC) reference CJC-1295 (No DAC) storage CJC-1295 (No DAC) reconstitution CJC-1295 (No DAC) calculatorCJC-1295 (No DAC) product details

Kisspeptin reference

Full Kisspeptin reference Kisspeptin storage Kisspeptin reconstitution Kisspeptin calculatorKisspeptin product details

Related comparisons

5-Amino-1MQ vs CJC-1295 (No DAC)CJC-1295 (No DAC) vs CJC-1295 + IpamorelinCJC-1295 (No DAC) vs IGF-1CJC-1295 (No DAC) vs IGF-1 LR3CJC-1295 (No DAC) vs IpamorelinCJC-1295 (No DAC) vs MOTS-CCJC-1295 (No DAC) vs NAD+CJC-1295 (No DAC) vs PT-141 (Bremelanotide)

CJC-1295 (No DAC) and Kisspeptin are supplied strictly as research chemicals for in-vitro laboratory and research use only. They are not intended for human or animal consumption, diagnostic, or therapeutic use. This comparison summarizes published preclinical literature and laboratory handling data; it is not medical advice, not a claim of efficacy, and not usage guidance.