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Research Comparison

CJC-1295 (No DAC) vs Tesamorelin

Two engineering answers to the same problem — native GHRH is destroyed within minutes — reached from opposite directions.

Shared research areas:Hormonal & EndocrineMetabolic
ClassGHRH(1-29) tetra-substituted analogue (DAC-free)Full-length 44-residue GHRH analogue with trans-3-hexenoic acid modification
Molecular weight3367.9 g/mol5135.0 g/mol
CAS numberNot assigned / not specifiedNot assigned / not specified
Purity spec≥99%≥99%
Research areasHormonal & Endocrine, MetabolicHormonal & Endocrine, Metabolic
Primary diluentBacteriostatic water (0.9% benzyl alcohol)Bacteriostatic water (0.9% benzyl alcohol)
Working windowCommonly worked with for 2-3 weeks at 2-8 °C.Commonly worked with for 2–3 weeks at 2–8 °C.
Lead degradation routeDeamidation at Asn/Gln residues over long solution storage.Aggregation at air–liquid interfaces from agitation — the practical failure mode for longer chains.
Freeze–thawAliquot on first reconstitution; avoid re-freezing the solution.Do not freeze reconstituted material. At this chain length, interfacial aggregation during freezing is a real risk.
Light sensitivityNo specific light requirement beyond normal practice.No specific light requirement beyond normal practice.

How they actually differ

Tesamorelin keeps the full 44-residue GHRH sequence and caps its front end to block the protease. CJC-1295 without DAC truncates to the first 29 residues and rebuilds the same resistance through four internal substitutions. Cap-the-end versus rewrite-the-middle. Both dissolve in plain water and are refrigerated after mixing; both have amphipathic coils that foam if shaken, so both ask for a gentle swirl.

CJC-1295 (No DAC) — origin

CJC-1295 without DAC is the first 29 residues of growth-hormone-releasing hormone carrying four stabilising substitutions (D-Ala2, Gln8, Ala15, Leu27) that resist DPP-4 cleavage. Omitting the Drug Affinity Complex — the albumin-binding element of the DAC version — gives it a short half-life, which is the property researchers study it for.

Tesamorelin — origin

Tesamorelin is the complete 44-amino-acid sequence of human growth hormone-releasing hormone with a trans-3-hexenoic acid group attached at the N-terminus. That modification exists for one reason: native GHRH is cleaved almost immediately by dipeptidyl peptidase-4 at the N-terminal end, and the hexenoyl group blocks that cleavage.

CJC-1295 (No DAC) research themes

Pulsatile GH release

Studied for prompting growth-hormone release in short, physiological pulses via the GHRH receptor.

DPP-4 resistance

The four substitutions are studied for extending the molecule beyond the minutes-long survival of native GHRH.

Complementary pairing

Frequently studied alongside ghrelin-receptor secretagogues such as Ipamorelin, which recruit a second GH-release pathway.

Tesamorelin research themes

GHRH receptor agonism

Full-length GHRH activity with DPP-4 resistance conferred by the N-terminal modification.

Visceral adipose tissue

The most distinctive endpoint in its research literature.

GH pulsatility

Studied for effects on endogenous GH secretion patterns rather than direct GH substitution.

Metabolic parameters

Investigated alongside body-composition endpoints in metabolic research.

CJC-1295 (No DAC) handling

  • Reach room temperature before opening.
  • Swirl to dissolve; do not shake or vortex — foam indicates interfacial stress on the helix.
  • Aliquot and refrigerate; never re-freeze reconstituted solution.

Tesamorelin handling

  • Allow several minutes for dissolution; do not accelerate with agitation or heat.
  • Swirl gently — long chains aggregate at interfaces.
  • Do not freeze reconstituted solution.

Both third-party tested

Every Popular Peptides batch of CJC-1295 (No DAC) and Tesamorelin is independently tested by HPLC and LC-MS with a published Certificate of Analysis. Enter a lot number to pull the COA for a specific vial.

Verify a batchPublished COAsHow we test

CJC-1295 (No DAC) reference

Full CJC-1295 (No DAC) reference CJC-1295 (No DAC) storage CJC-1295 (No DAC) reconstitution CJC-1295 (No DAC) calculatorCJC-1295 (No DAC) product details

Tesamorelin reference

Full Tesamorelin reference Tesamorelin storage Tesamorelin reconstitution Tesamorelin calculatorTesamorelin product details

Related comparisons

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CJC-1295 (No DAC) and Tesamorelin are supplied strictly as research chemicals for in-vitro laboratory and research use only. They are not intended for human or animal consumption, diagnostic, or therapeutic use. This comparison summarizes published preclinical literature and laboratory handling data; it is not medical advice, not a claim of efficacy, and not usage guidance.