PT-141 (Bremelanotide)
Synthetic melanocortin-receptor peptide (bremelanotide), lyophilised. For in vitro research use only.
Key facts
- Compound:
- PT-141 (Bremelanotide)
- Purity:
- ≥99%, verified by HPLC
- Identity confirmed by:
- LC-MS, independent third-party lab
- CAS number:
- 189691-06-3
- Molecular weight:
- 1025.2 g/mol
- Certificate of analysis:
- available on request, verifiable by lot number
- Ships from:
- Vancouver, BC — typically 2–5 business days, tracked and insured, no customs
- Intended use:
- in vitro laboratory research only — not for human or veterinary consumption
Page last updated
PT-141 (bremelanotide) is a synthetic melanocortin-receptor peptide.
PT-141 (Bremelanotide) for reproductive-axis research, shipped Canada-wide from Vancouver. One 10 mg vial, ≥99% purity, CAS 189691-06-3, molecular weight 1025.2 g/mol. Identity and purity are confirmed by independent HPLC and LC-MS, with the batch-specific Certificate of Analysis available on request. Every lot number is verifiable at popularpeptides.ca/verify. Tracked, insured delivery across Canada — typically 2 to 5 business days, with no customs step and no brokerage fee.
Supplied lyophilised for in vitro laboratory research use only; not intended for human or veterinary use.
Primary literature
- FDA approval of Vyleesi (bremelanotide) for hypoactive sexual desire disorder in premenopausal women — U.S. Food and Drug Administration, 2019
Regulatory record for the pharmaceutical form. Research-grade material is not the approved product.
Cited for research context. A citation is not a claim that this compound is safe, effective, or approved for any use.
⚠️ Research Use Only. This compound is intended for in vitro research and laboratory use only. Not for human or veterinary consumption.
PT-141 — compound background
Cyclic heptapeptide, melanocortin receptor agonist
PT-141 is a metabolite of Melanotan II, and its history is an unusually direct case of a side effect becoming the research programme. Melanotan II was developed as a synthetic α-MSH analogue for pigmentation research; an unanticipated effect observed during that work redirected attention to the metabolite, which was then developed separately as bremelanotide.
Solubility & reconstitution
Water-soluble and straightforward to reconstitute. The molecule is cyclic — closed through a lactam bridge rather than a disulfide — which makes it conformationally constrained and notably more rigid than a linear peptide of similar length.
Storage
Sealed at -20 °C, dry and protected from light. Refrigerate at 2–8 °C, protected from light on account of the tryptophan residue.
Commonly worked with for 2–4 weeks at 2–8 °C.
Stability
Worth distinguishing from oxytocin: both are cyclic, but PT-141 closes through a lactam (an amide bond) rather than a disulfide. Amide bonds do not undergo the exchange and scrambling chemistry that dominates oxytocin degradation, so the cyclic structure here is a stability asset rather than a liability.
Reading the Certificate of Analysis
Confirm the mass near 1025.2 Da and check for oxidised (+16 Da) species from the tryptophan. Also confirm the cyclic form: a linear (uncyclised) impurity differs by 18 Da from the cyclised product, since ring closure eliminates a water molecule.
Background and handling information is educational, for in-vitro laboratory research use only — not medical advice, dosing, or usage guidance, and not a description of use in humans or animals.
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PT-141 laboratory reference
PT-141 (Bremelanotide) is cyclic heptapeptide, melanocortin receptor agonist. Handling requirements follow from that chemistry rather than from generic peptide guidance — the pages below cover each aspect specifically for this compound.
Lyophilized and reconstituted storage conditions, plus the practical working window.
Diluent selection, dissolution behaviour, and the calculator preset for this compound.
Which solvents work, why, and what abnormal dissolution behaviour indicates.
The specific chemical routes by which this molecule breaks down, and how to limit each.
Which assays are informative for this molecule, and what to actually check on its COA.
Compound-specific bench practices, and the errors most often made with this molecule.
What to inspect on arrival, and which conditions actually warrant rejecting a vial.
Questions specific to this compound — structure, chemistry, and common misconceptions.
PT-141 compared with
Reference content is educational laboratory-handling information for in-vitro research use only — not medical advice, not usage guidance, and not a protocol.